Detailed information of TA system TA042655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 1763821..1764283
• Replicon: chromosome
• Accession: NZ_AP026780
• Organism: Photobacterium damselae subsp. damselae strain 04Ya311

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7Y7QCC3
• Locus tag: OO966_RS08320
• Protein ID: WP_068946750.1
• Coordinates: 1763821..1764105 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OO966_RS08325
• Protein ID: WP_217908133.1
• Coordinates: 1764095..1764283 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO966_RS08285 (PDY_15500)	1759321..1760109	+	789	WP_264954202.1	RecX family transcriptional regulator	-
OO966_RS08290 (PDY_15510)	1760146..1760598	-	453	WP_264954203.1	N-acetyltransferase	-
OO966_RS08295 (PDY_15520)	1760661..1760993	-	333	WP_264954204.1	DUF4377 domain-containing protein	-
OO966_RS08300 (PDY_15530)	1761156..1761440	+	285	WP_106261788.1	damage-inducible protein J	-
OO966_RS08305 (PDY_15540)	1761559..1761906	-	348	WP_036763975.1	hydrogenase maturation nickel metallochaperone HypA	-
OO966_RS08310 (PDY_15550)	1761921..1762658	-	738	WP_068969267.1	hydrogenase nickel incorporation protein HypB	-
OO966_RS08315 (PDY_15560)	1762989..1763558	+	570	WP_264954206.1	hypothetical protein	-
OO966_RS08320 (PDY_15570)	1763821..1764105	-	285	WP_068946750.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO966_RS08325 (PDY_15580)	1764095..1764283	-	189	WP_217908133.1	antitoxin	Antitoxin
OO966_RS08330 (PDY_15590)	1764698..1765093	-	396	WP_264954208.1	hypothetical protein	-
OO966_RS08335 (PDY_15600)	1765335..1765892	-	558	WP_005299673.1	heme utilization protein HutZ	-
OO966_RS08340 (PDY_15610)	1765892..1766416	-	525	WP_044175768.1	heme utilization cystosolic carrier protein HutX	-
OO966_RS08345 (PDY_15620)	1766470..1767861	-	1392	WP_138242553.1	heme anaerobic degradation radical SAM methyltransferase ChuW/HutW	-
OO966_RS08350 (PDY_15630)	1768258..1769016	+	759	WP_264954215.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp1 / icmF/vasK / clpB/vasG / vasE / vasA / vipB/mglB / vipA/mglA	1407714..1774617	366903

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11147.24 Da
• Isoelectric Point: 10.6691

>T42655 WP_068946750.1 NZ_AP026780:c1764105-1763821 [Photobacterium damselae subsp. damselae]
VTYRLAIKEEAQKEWKKLNTNIQMQFKKKLVERLENPHVLASKLSNMPNCYKIKLRSAGYRLVYEVRDKDIVVIVIAVGK
RERNEVYKTAIKRL

Nucleotide

• Length: 285 bp

>T42655 NZ_AP026780:c1764105-1763821 [Photobacterium damselae subsp. damselae]
GTGACTTATAGATTAGCTATTAAAGAAGAAGCACAAAAAGAATGGAAAAAACTAAACACTAATATACAAATGCAATTCAA
AAAGAAATTGGTTGAGCGTTTAGAGAATCCACACGTCTTAGCTTCAAAGCTGAGTAATATGCCGAACTGCTATAAAATTA
AATTAAGAAGTGCAGGTTATCGGCTTGTTTACGAAGTACGTGATAAAGATATTGTTGTTATAGTGATCGCAGTTGGTAAA
CGTGAAAGAAACGAAGTATATAAAACAGCGATAAAACGACTATAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7085.00 Da
• Isoelectric Point: 4.0780

>AT42655 WP_217908133.1 NZ_AP026780:c1764283-1764095 [Photobacterium damselae subsp. damselae]
MSVVNDTDGFPVAVLNHNQPAFYCIPADAYEMLLDKLEDVELADLVRKRRNSKEFEIDISDL

Nucleotide

• Length: 189 bp

>AT42655 NZ_AP026780:c1764283-1764095 [Photobacterium damselae subsp. damselae]
ATGTCTGTAGTTAATGATACGGATGGCTTTCCTGTCGCTGTTTTGAATCATAACCAGCCAGCTTTTTATTGCATCCCTGC
CGATGCGTATGAAATGCTCTTAGATAAATTAGAAGATGTTGAGCTTGCAGATCTCGTAAGAAAACGTCGCAATTCAAAAG
AATTTGAGATCGATATTAGTGACTTATAG

Structures

Toxin

• AlphaFold DB: A0A7Y7QCC3