Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 4313..4832 | Replicon | plasmid pNUITMVRE1_2 |
Accession | NZ_AP026775 | ||
Organism | Enterococcus faecium strain NUITM-VRE1 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | OO969_RS15680 | Protein ID | WP_000588503.1 |
Coordinates | 4575..4832 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | OO969_RS15675 | Protein ID | WP_000388479.1 |
Coordinates | 4313..4582 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OO969_RS15645 (NUITMVRE1_30910) | 303..587 | - | 285 | WP_000353844.1 | hypothetical protein | - |
OO969_RS15650 (NUITMVRE1_30920) | 953..1177 | + | 225 | WP_000410576.1 | hypothetical protein | - |
OO969_RS15655 (NUITMVRE1_30930) | 2300..2980 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
OO969_RS15660 (NUITMVRE1_30940) | 3056..3622 | + | 567 | Protein_4 | hypothetical protein | - |
OO969_RS15665 | 3787..3987 | + | 201 | WP_001033544.1 | 4-hydroxybenzoate octaprenyltransferase | - |
OO969_RS15670 (NUITMVRE1_30950) | 4003..4182 | + | 180 | WP_001120991.1 | hypothetical protein | - |
OO969_RS15675 (NUITMVRE1_30960) | 4313..4582 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
OO969_RS15680 (NUITMVRE1_30970) | 4575..4832 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
OO969_RS15685 (NUITMVRE1_30980) | 5470..6078 | + | 609 | WP_224752223.1 | hypothetical protein | - |
OO969_RS15690 (NUITMVRE1_30990) | 6212..7531 | + | 1320 | WP_000202380.1 | IS1380-like element IS1678 family transposase | - |
OO969_RS15695 (NUITMVRE1_31000) | 7744..7977 | + | 234 | WP_002296232.1 | hypothetical protein | - |
OO969_RS15700 (NUITMVRE1_31010) | 8142..8756 | - | 615 | WP_001261742.1 | recombinase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | VanHAX | - | 1..28491 | 28491 | |
- | inside | IScluster/Tn | - | - | 2300..7531 | 5231 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T42654 WP_000588503.1 NZ_AP026775:4575-4832 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T42654 NZ_AP026775:4575-4832 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT42654 WP_000388479.1 NZ_AP026775:4313-4582 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT42654 NZ_AP026775:4313-4582 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |