Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 72248..72767 | Replicon | plasmid pNUITMVRE1_1 |
Accession | NZ_AP026774 | ||
Organism | Enterococcus faecium strain NUITM-VRE1 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | OO969_RS14730 | Protein ID | WP_000588503.1 |
Coordinates | 72510..72767 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | OO969_RS14725 | Protein ID | WP_000388479.1 |
Coordinates | 72248..72517 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OO969_RS14715 (NUITMVRE1_28990) | 68480..70360 | + | 1881 | WP_002337940.1 | beta-glucoside-specific PTS transporter subunit IIABC | - |
OO969_RS14720 (NUITMVRE1_29000) | 70376..71797 | + | 1422 | WP_010861609.1 | family 1 glycosylhydrolase | - |
OO969_RS14725 (NUITMVRE1_29010) | 72248..72517 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
OO969_RS14730 (NUITMVRE1_29020) | 72510..72767 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
OO969_RS14735 (NUITMVRE1_29030) | 72947..73327 | + | 381 | WP_264879946.1 | adenylate/guanylate cyclase domain-containing protein | - |
OO969_RS14740 (NUITMVRE1_29040) | 73365..74045 | + | 681 | WP_010710189.1 | IS6-like element IS1216 family transposase | - |
OO969_RS14745 (NUITMVRE1_29050) | 74087..74776 | + | 690 | WP_264879947.1 | IS6-like element IS1216 family transposase | - |
OO969_RS14750 (NUITMVRE1_29060) | 75056..75478 | + | 423 | WP_002303116.1 | hypothetical protein | - |
OO969_RS14755 (NUITMVRE1_29070) | 75488..75691 | + | 204 | WP_002299573.1 | hypothetical protein | - |
OO969_RS14760 (NUITMVRE1_29080) | 75902..76486 | + | 585 | WP_002299575.1 | recombinase family protein | - |
OO969_RS14765 (NUITMVRE1_29090) | 76675..77355 | - | 681 | WP_010861579.1 | IS6-like element IS1216 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..235911 | 235911 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T42652 WP_000588503.1 NZ_AP026774:72510-72767 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T42652 NZ_AP026774:72510-72767 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCTCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAGTGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCTCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAGTGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT42652 WP_000388479.1 NZ_AP026774:72248-72517 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT42652 NZ_AP026774:72248-72517 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |