Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 192888..193417 Replicon chromosome
Accession NZ_AP026772
Organism Enterococcus faecium strain NUITM-VRE1

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag OO969_RS00940 Protein ID WP_002296560.1
Coordinates 193151..193417 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag OO969_RS00935 Protein ID WP_002296559.1
Coordinates 192888..193151 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO969_RS00925 (NUITMVRE1_01860) 190262..192085 + 1824 WP_002294202.1 APC family permease -
OO969_RS00930 (NUITMVRE1_01870) 192227..192412 - 186 WP_002296558.1 transcriptional regulator -
OO969_RS00935 (NUITMVRE1_01880) 192888..193151 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO969_RS00940 (NUITMVRE1_01890) 193151..193417 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
OO969_RS00945 (NUITMVRE1_01900) 193618..194106 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
OO969_RS00950 (NUITMVRE1_01910) 194647..195300 - 654 WP_002323018.1 ABC transporter permease -
OO969_RS00955 (NUITMVRE1_01920) 195315..196232 - 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
OO969_RS00960 (NUITMVRE1_01930) 196229..196870 - 642 WP_002293405.1 ABC transporter permease -
OO969_RS00965 (NUITMVRE1_01940) 196874..198049 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T42648 WP_002296560.1 NZ_AP026772:193151-193417 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T42648 NZ_AP026772:193151-193417 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT42648 WP_002296559.1 NZ_AP026772:192888-193151 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT42648 NZ_AP026772:192888-193151 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References