Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1590115..1590643 Replicon chromosome
Accession NZ_AP026765
Organism Vibrio sp. STUT-A16

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag OO778_RS07605 Protein ID WP_005377002.1
Coordinates 1590115..1590405 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag OO778_RS07610 Protein ID WP_005377003.1
Coordinates 1590395..1590643 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO778_RS07570 (VspSTUT16_13750) 1585527..1585856 + 330 WP_074190749.1 hypothetical protein -
OO778_RS07575 1585856..1585930 + 75 Protein_1415 DUF3265 domain-containing protein -
OO778_RS07580 1587116..1587514 - 399 WP_192943638.1 hypothetical protein -
OO778_RS07585 1587604..1587693 + 90 WP_074190757.1 DUF3265 domain-containing protein -
OO778_RS07590 (VspSTUT16_13770) 1587721..1588197 + 477 WP_057619450.1 GNAT family N-acetyltransferase -
OO778_RS07595 1588194..1588262 + 69 Protein_1419 DUF3265 domain-containing protein -
OO778_RS07600 (VspSTUT16_13780) 1588352..1588825 + 474 WP_264911083.1 hypothetical protein -
OO778_RS07605 (VspSTUT16_13790) 1590115..1590405 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO778_RS07610 (VspSTUT16_13800) 1590395..1590643 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO778_RS07615 (VspSTUT16_13810) 1590841..1592052 + 1212 WP_256935573.1 HEPN domain-containing protein -
OO778_RS07620 1592067..1592159 + 93 WP_226977467.1 DUF3265 domain-containing protein -
OO778_RS07625 (VspSTUT16_13830) 1592187..1592699 + 513 WP_104969515.1 GNAT family N-acetyltransferase -
OO778_RS07630 1592737..1592829 + 93 WP_192943636.1 DUF3265 domain-containing protein -
OO778_RS07635 (VspSTUT16_13840) 1592929..1593231 - 303 WP_104969512.1 hypothetical protein -
OO778_RS07640 1593357..1593449 + 93 WP_104969511.1 DUF3265 domain-containing protein -
OO778_RS07645 1593868..1593997 + 130 Protein_1429 DUF3265 domain-containing protein -
OO778_RS07650 (VspSTUT16_13850) 1594030..1594482 + 453 WP_226977466.1 GNAT family N-acetyltransferase -
OO778_RS07655 1595088..1595165 + 78 Protein_1431 DUF3265 domain-containing protein -
OO778_RS07660 (VspSTUT16_13860) 1595248..1595535 + 288 WP_129830247.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1354859..1680644 325785
- inside Integron - - 1559052..1640187 81135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T42647 WP_005377002.1 NZ_AP026765:c1590405-1590115 [Vibrio sp. STUT-A16]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T42647 NZ_AP026765:c1590405-1590115 [Vibrio sp. STUT-A16]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCAGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGAGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT42647 WP_005377003.1 NZ_AP026765:c1590643-1590395 [Vibrio sp. STUT-A16]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT42647 NZ_AP026765:c1590643-1590395 [Vibrio sp. STUT-A16]
ATGACCACTAGAATATTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTTGCTGTATTGAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References