Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1540547..1541112 Replicon chromosome
Accession NZ_AP026763
Organism Vibrio sp. STUT-A11

Toxin (Protein)


Gene name relE Uniprot ID A0A4U1W7G7
Locus tag OO774_RS07265 Protein ID WP_053815743.1
Coordinates 1540825..1541112 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3NI65
Locus tag OO774_RS07260 Protein ID WP_011080399.1
Coordinates 1540547..1540828 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO774_RS07235 (VspSTUT11_13410) 1536067..1537479 - 1413 WP_264905814.1 tyrosine-type recombinase/integrase -
OO774_RS07240 1537617..1537706 + 90 WP_079725283.1 DUF3265 domain-containing protein -
OO774_RS07245 (VspSTUT11_13420) 1537735..1538388 + 654 WP_264905815.1 GIY-YIG nuclease family protein -
OO774_RS07250 1539024..1539113 + 90 WP_077681816.1 DUF3265 domain-containing protein -
OO774_RS07255 (VspSTUT11_13430) 1539134..1540333 - 1200 WP_263837029.1 IS4 family transposase -
OO774_RS07260 (VspSTUT11_13440) 1540547..1540828 + 282 WP_011080399.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO774_RS07265 (VspSTUT11_13450) 1540825..1541112 + 288 WP_053815743.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO774_RS07270 (VspSTUT11_13460) 1541291..1541581 + 291 WP_264905825.1 hypothetical protein -
OO774_RS07275 (VspSTUT11_13470) 1541744..1542448 + 705 WP_264905827.1 hypothetical protein -
OO774_RS07280 (VspSTUT11_13480) 1542585..1542971 + 387 WP_045595986.1 tautomerase family protein -
OO774_RS07285 (VspSTUT11_13490) 1543099..1544298 - 1200 WP_263837029.1 IS4 family transposase -
OO774_RS07290 (VspSTUT11_13500) 1544449..1544916 + 468 WP_264905830.1 GNAT family N-acetyltransferase -
OO774_RS07295 (VspSTUT11_13510) 1545070..1545429 + 360 WP_264905831.1 VOC family protein -
OO774_RS07300 (VspSTUT11_13520) 1545566..1546075 + 510 WP_264905833.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1545070..1575680 30610
- inside Integron - - 1537735..1566854 29119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10961.60 Da        Isoelectric Point: 5.0872

>T42643 WP_053815743.1 NZ_AP026763:1540825-1541112 [Vibrio sp. STUT-A11]
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTELLSSMPEMGRTVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQMLTESDV

Download         Length: 288 bp

>T42643 NZ_AP026763:1540825-1541112 [Vibrio sp. STUT-A11]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTCATTTCACTGGATAACCCAGTGGC
GGCAGAAAACTGGGTTAATGAGGTTTTCGATAAAACTGAACTACTCTCAAGTATGCCTGAAATGGGGCGAACGGTTCCTG
AACTACCTCATACCAATTATCGCGAAATCTTGTTTGGTCACTATCGAATCATTTATAGCCTCAGCCATGAAATTCGTGTC
CTCACTGTACGAAATTGTCGTCAAATGCTAACTGAAAGTGACGTGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10426.96 Da        Isoelectric Point: 5.8719

>AT42643 WP_011080399.1 NZ_AP026763:1540547-1540828 [Vibrio sp. STUT-A11]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Download         Length: 282 bp

>AT42643 NZ_AP026763:1540547-1540828 [Vibrio sp. STUT-A11]
ATGAGCCGCATCCACTTTGATCAAGATATTCAGCCTTTGTCTGAATTTCGTGCTGGGGTAACGTCATTTATTAAGCAGAT
TAACGAAACTCGCAGACCATTAGTAATCACACAACGTGGTAAGGGTGTTGCAGTTGTCCTTGATGTTGCAGAATATGAAG
CAATGCAAGAGAAGATCGAGTTACTGGAGGAAATGCGTACTGCTGAAGCACAGCTAGCTTCAGGTTTAGGTGTTTCTAAT
GAAGATGCTCGCGCTCAAGTGTTGGGGCGTATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U1W7G7

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0MQY5

References