Detailed information of TA system TA042642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1369956..1370497
• Replicon: chromosome
• Accession: NZ_AP026763
• Organism: Vibrio sp. STUT-A11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OO774_RS06595
• Protein ID: WP_264905689.1
• Coordinates: 1369956..1370216 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: OO774_RS06600
• Protein ID: WP_005398409.1
• Coordinates: 1370213..1370497 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO774_RS06555 (VspSTUT11_12020)	1366242..1366739	-	498	WP_017053840.1	GNAT family N-acetyltransferase	-
OO774_RS06560 (VspSTUT11_12030)	1366736..1367008	-	273	WP_017420534.1	DUF1778 domain-containing protein	-
OO774_RS06565	1367118..1367210	+	93	WP_079852074.1	DUF3265 domain-containing protein	-
OO774_RS06570 (VspSTUT11_12040)	1367243..1367914	+	672	WP_264905682.1	hypothetical protein	-
OO774_RS06575	1368138..1368272	+	135	WP_264905683.1	hypothetical protein	-
OO774_RS06580 (VspSTUT11_12050)	1368758..1369075	+	318	WP_264905684.1	hypothetical protein	-
OO774_RS06585 (VspSTUT11_12060)	1369297..1369563	+	267	WP_264905685.1	BrnT family toxin	-
OO774_RS06590 (VspSTUT11_12070)	1369550..1369792	+	243	WP_264905687.1	BrnA antitoxin family protein	-
OO774_RS06595 (VspSTUT11_12080)	1369956..1370216	-	261	WP_264905689.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO774_RS06600 (VspSTUT11_12090)	1370213..1370497	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OO774_RS06605	1370574..1370666	+	93	WP_079399698.1	DUF3265 domain-containing protein	-
OO774_RS06610 (VspSTUT11_12100)	1370851..1371066	+	216	WP_264905693.1	hypothetical protein	-
OO774_RS06615 (VspSTUT11_12110)	1371361..1372215	-	855	WP_264905695.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1362408..1370679	8271

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10202.84 Da
• Isoelectric Point: 4.3135

>T42642 WP_264905689.1 NZ_AP026763:c1370216-1369956 [Vibrio sp. STUT-A11]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQK

Nucleotide

• Length: 261 bp

>T42642 NZ_AP026763:c1370216-1369956 [Vibrio sp. STUT-A11]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAATTTGCTAGAGCAGCCTCTTATGGGTGTACAGCGAGACGGTA
TTCGTGGGCGATTACTTATAATTCCTGAGATTTCGATGATCGTATCTTATTGGATCGAAGGCGACATTATCCGAATCATG
CGCGTACTCCACCAGAAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT42642 WP_005398409.1 NZ_AP026763:c1370497-1370213 [Vibrio sp. STUT-A11]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT42642 NZ_AP026763:c1370497-1370213 [Vibrio sp. STUT-A11]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAGATGGCTGAGAGCCAAGGTCGCAC
ACTGAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCATCAAACTGCTAAATCTCGA
ATGGAAGAACGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A347UR21