Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1366242..1367008 Replicon chromosome
Accession NZ_AP026763
Organism Vibrio sp. STUT-A11

Toxin (Protein)


Gene name - Uniprot ID A0A432DAA5
Locus tag OO774_RS06555 Protein ID WP_017053840.1
Coordinates 1366242..1366739 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag OO774_RS06560 Protein ID WP_017420534.1
Coordinates 1366736..1367008 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO774_RS06515 (VspSTUT11_11960) 1361266..1361580 + 315 WP_089202944.1 DNA-binding transcriptional regulator -
OO774_RS06520 1362201..1362292 + 92 Protein_1204 DUF3265 domain-containing protein -
OO774_RS06525 (VspSTUT11_11970) 1362402..1363193 + 792 WP_264905662.1 PhzF family phenazine biosynthesis protein -
OO774_RS06530 1363193..1363318 + 126 WP_264905664.1 DUF3265 domain-containing protein -
OO774_RS06535 (VspSTUT11_11980) 1363345..1363779 + 435 WP_264905666.1 GNAT family N-acetyltransferase -
OO774_RS06540 (VspSTUT11_11990) 1363952..1364368 + 417 WP_264905668.1 hypothetical protein -
OO774_RS06545 (VspSTUT11_12000) 1364347..1364751 + 405 WP_264905670.1 hypothetical protein -
OO774_RS06550 (VspSTUT11_12010) 1364886..1366085 - 1200 WP_263837029.1 IS4 family transposase -
OO774_RS06555 (VspSTUT11_12020) 1366242..1366739 - 498 WP_017053840.1 GNAT family N-acetyltransferase Toxin
OO774_RS06560 (VspSTUT11_12030) 1366736..1367008 - 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
OO774_RS06565 1367118..1367210 + 93 WP_079852074.1 DUF3265 domain-containing protein -
OO774_RS06570 (VspSTUT11_12040) 1367243..1367914 + 672 WP_264905682.1 hypothetical protein -
OO774_RS06575 1368138..1368272 + 135 WP_264905683.1 hypothetical protein -
OO774_RS06580 (VspSTUT11_12050) 1368758..1369075 + 318 WP_264905684.1 hypothetical protein -
OO774_RS06585 (VspSTUT11_12060) 1369297..1369563 + 267 WP_264905685.1 BrnT family toxin -
OO774_RS06590 (VspSTUT11_12070) 1369550..1369792 + 243 WP_264905687.1 BrnA antitoxin family protein -
OO774_RS06595 (VspSTUT11_12080) 1369956..1370216 - 261 WP_264905689.1 type II toxin-antitoxin system RelE/ParE family toxin -
OO774_RS06600 (VspSTUT11_12090) 1370213..1370497 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
OO774_RS06605 1370574..1370666 + 93 WP_079399698.1 DUF3265 domain-containing protein -
OO774_RS06610 (VspSTUT11_12100) 1370851..1371066 + 216 WP_264905693.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1362408..1370679 8271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18458.12 Da        Isoelectric Point: 8.8085

>T42640 WP_017053840.1 NZ_AP026763:c1366739-1366242 [Vibrio sp. STUT-A11]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T42640 NZ_AP026763:c1366739-1366242 [Vibrio sp. STUT-A11]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGTCTGATCGCCCGTCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCTTTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT42640 WP_017420534.1 NZ_AP026763:c1367008-1366736 [Vibrio sp. STUT-A11]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT42640 NZ_AP026763:c1367008-1366736 [Vibrio sp. STUT-A11]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAAGCTGCCGCGATCGC
TGGCATGTCTAGCATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCTGATGCGATGTTGCTTATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A432DAA5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References