Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1351466..1352013 | Replicon | chromosome |
| Accession | NZ_AP026763 | ||
| Organism | Vibrio sp. STUT-A11 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A7Y0S5Y1 |
| Locus tag | OO774_RS06435 | Protein ID | WP_025796191.1 |
| Coordinates | 1351711..1352013 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR20 |
| Locus tag | OO774_RS06430 | Protein ID | WP_005398415.1 |
| Coordinates | 1351466..1351723 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO774_RS06390 (VspSTUT11_11770) | 1346669..1347073 | + | 405 | WP_264905634.1 | DUF1801 domain-containing protein | - |
| OO774_RS06395 (VspSTUT11_11780) | 1347144..1347497 | + | 354 | WP_264905636.1 | hypothetical protein | - |
| OO774_RS06400 | 1347534..1347626 | + | 93 | WP_223295745.1 | DUF3265 domain-containing protein | - |
| OO774_RS06405 | 1348144..1348236 | + | 93 | WP_264905639.1 | DUF3265 domain-containing protein | - |
| OO774_RS06410 (VspSTUT11_11790) | 1348257..1349456 | - | 1200 | WP_263837029.1 | IS4 family transposase | - |
| OO774_RS06415 (VspSTUT11_11800) | 1349764..1349979 | + | 216 | WP_228841545.1 | hypothetical protein | - |
| OO774_RS06420 | 1350140..1350190 | + | 51 | WP_233263896.1 | hypothetical protein | - |
| OO774_RS06425 (VspSTUT11_11810) | 1350223..1350696 | + | 474 | WP_264905642.1 | GNAT family N-acetyltransferase | - |
| OO774_RS06430 (VspSTUT11_11820) | 1351466..1351723 | + | 258 | WP_005398415.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OO774_RS06435 (VspSTUT11_11830) | 1351711..1352013 | + | 303 | WP_025796191.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO774_RS06440 | 1352052..1352141 | + | 90 | WP_140222607.1 | DUF3265 domain-containing protein | - |
| OO774_RS06445 | 1352598..1352687 | + | 90 | WP_264906080.1 | DUF3265 domain-containing protein | - |
| OO774_RS06450 (VspSTUT11_11840) | 1352708..1353907 | - | 1200 | WP_263837029.1 | IS4 family transposase | - |
| OO774_RS06455 (VspSTUT11_11850) | 1354060..1354569 | + | 510 | WP_264905646.1 | CbrC family protein | - |
| OO774_RS06460 (VspSTUT11_11860) | 1354724..1355137 | + | 414 | WP_264905647.1 | GIY-YIG nuclease family protein | - |
| OO774_RS06465 (VspSTUT11_11870) | 1355295..1355687 | + | 393 | WP_264905649.1 | hypothetical protein | - |
| OO774_RS06470 | 1355714..1355806 | + | 93 | WP_264905651.1 | DUF3265 domain-containing protein | - |
| OO774_RS06475 (VspSTUT11_11880) | 1355902..1356117 | + | 216 | WP_264905652.1 | DUF4177 domain-containing protein | - |
| OO774_RS06480 (VspSTUT11_11890) | 1356138..1356344 | + | 207 | WP_264905653.1 | membrane protein insertion efficiency factor YidD | - |
| OO774_RS06485 (VspSTUT11_11900) | 1356344..1356733 | + | 390 | WP_264905654.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1330678..1358881 | 28203 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11655.54 Da Isoelectric Point: 5.1765
>T42637 WP_025796191.1 NZ_AP026763:1351711-1352013 [Vibrio sp. STUT-A11]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T42637 NZ_AP026763:1351711-1352013 [Vibrio sp. STUT-A11]
ATGGCTGAAGTAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATAGCACTGGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CTGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCGGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA
ATGGCTGAAGTAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATAGCACTGGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CTGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCGGAGAGAGATTTGCGTAAGTTCTTGTTGAGTAAGCAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9578.04 Da Isoelectric Point: 6.7269
>AT42637 WP_005398415.1 NZ_AP026763:1351466-1351723 [Vibrio sp. STUT-A11]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVASHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVASHDEAKDKM
SKWLK
Download Length: 258 bp
>AT42637 NZ_AP026763:1351466-1351723 [Vibrio sp. STUT-A11]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATTTAGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTGGCAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATTTAGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTGGCAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y0S5Y1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR20 |