Detailed information of TA system TA042632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2775781..2776346
• Replicon: chromosome
• Accession: NZ_AP026732
• Organism: Shewanella xiamenensis strain NUITM-VS2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8EGZ3
• Locus tag: OO995_RS12060
• Protein ID: WP_011071641.1
• Coordinates: 2776053..2776346 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: OO995_RS12055
• Protein ID: WP_172590110.1
• Coordinates: 2775781..2776065 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO995_RS12015 (NUITMVS2_23160)	2771014..2771520	+	507	WP_264888266.1	DNA repair protein RadC	-
OO995_RS12020 (NUITMVS2_23170)	2771558..2771920	+	363	WP_076500087.1	hypothetical protein	-
OO995_RS12025 (NUITMVS2_23180)	2772055..2772411	+	357	WP_264888271.1	type IV toxin-antitoxin system YeeU family antitoxin	-
OO995_RS12030 (NUITMVS2_23190)	2772656..2773069	+	414	WP_264888273.1	DUF2787 domain-containing protein	-
OO995_RS12035 (NUITMVS2_23200)	2773188..2773467	+	280	Protein_2310	site-specific integrase	-
OO995_RS12040 (NUITMVS2_23210)	2773600..2774007	+	408	WP_264888275.1	DUF2787 domain-containing protein	-
OO995_RS12045 (NUITMVS2_23220)	2774116..2774682	+	567	WP_264888276.1	site-specific integrase	-
OO995_RS12050 (NUITMVS2_23230)	2774771..2775493	+	723	WP_264888278.1	lecithin retinol acyltransferase family protein	-
OO995_RS12055 (NUITMVS2_23240)	2775781..2776065	+	285	WP_172590110.1	CopG family ribbon-helix-helix protein	Antitoxin
OO995_RS12060 (NUITMVS2_23250)	2776053..2776346	+	294	WP_011071641.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OO995_RS12065 (NUITMVS2_23260)	2776493..2777170	-	678	WP_086904680.1	inovirus Gp2 family protein	-
OO995_RS12070 (NUITMVS2_23270)	2777521..2778969	-	1449	WP_264888284.1	YfjI family protein	-
OO995_RS12075	2779007..2779219	-	213	WP_080612395.1	AlpA family phage regulatory protein	-
OO995_RS12080 (NUITMVS2_23280)	2779338..2780429	-	1092	WP_264888287.1	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11125.65 Da
• Isoelectric Point: 5.8404

>T42632 WP_011071641.1 NZ_AP026732:2776053-2776346 [Shewanella xiamenensis]
MPQIVFTATALRDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Nucleotide

• Length: 294 bp

>T42632 NZ_AP026732:2776053-2776346 [Shewanella xiamenensis]
ATGCCACAAATAGTCTTCACTGCCACTGCATTACGTGATTTAGAACGCTTACGTGAGTTTCTTCGCAGTAAAAATCCCCC
TGCCGCACAAAGGGCTGCCAGCGCCATAATCAATACCATTAGAAAACTGGAAAGCTATCCAGACATTGGTCGGCCTATCG
ATGACAATGACTTTAGCTTTAGGGAACTACTCATCGACTTTGGTGATACGGGTTATCTGGCAATGTACCAGTATGATGGA
GGCGAACGATTGACCGTATTGTGTATCCGTCACCAAAAAGAAGCCGGATATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10973.28 Da
• Isoelectric Point: 5.9920

>AT42632 WP_172590110.1 NZ_AP026732:2775781-2776065 [Shewanella xiamenensis]
MSTIKPVSVKLDADMKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEQAAPTCHK

Nucleotide

• Length: 285 bp

>AT42632 NZ_AP026732:2775781-2776065 [Shewanella xiamenensis]
ATGAGCACAATCAAACCCGTGTCGGTTAAATTAGATGCTGATATGAAAGCCAGAGTCGAGCATTTAGCCGAAACGCGTAA
ACGTTCATCACACTGGATGATGCGTGAAGCGATCCGTGAATACGTTGAGAGAGAAGAGAAACGCGAAGCTTTGCAGCAAG
AAGCGTTACGCGCATGGGAAGAACACCAGACATCAGGCTTGCATGTCACCGGTGACGAAGTGGTGAGTTGGCTGGAGTCC
TGGGGAAGTGAAAATGAACAGGCAGCCCCTACATGCCACAAATAG

Structures

Toxin

• PDB: 7ETR