Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 1598351..1599167 Replicon chromosome
Accession NZ_AP026732
Organism Shewanella xiamenensis strain NUITM-VS2

Toxin (Protein)


Gene name hepT Uniprot ID A0A252EQR5
Locus tag OO995_RS07085 Protein ID WP_069455295.1
Coordinates 1598351..1598752 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A501X4H4
Locus tag OO995_RS07090 Protein ID WP_069455294.1
Coordinates 1598745..1599167 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO995_RS07050 (NUITMVS2_13640) 1594122..1594469 + 348 WP_069455300.1 hypothetical protein -
OO995_RS07055 (NUITMVS2_13650) 1594466..1595146 - 681 WP_037428263.1 Sir2 family NAD-dependent protein deacetylase -
OO995_RS07060 1595250..1595849 - 600 WP_069455299.1 metallophosphoesterase -
OO995_RS07065 1595858..1596271 - 414 WP_069455298.1 hypothetical protein -
OO995_RS07070 (NUITMVS2_13670) 1596268..1596570 - 303 WP_069455297.1 hypothetical protein -
OO995_RS07075 (NUITMVS2_13680) 1597126..1598157 + 1032 WP_069455296.1 dTDP-glucose 4,6-dehydratase -
OO995_RS07080 1598223..1598348 - 126 WP_264889444.1 hypothetical protein -
OO995_RS07085 (NUITMVS2_13690) 1598351..1598752 - 402 WP_069455295.1 type II toxin-antitoxin system toxin Toxin
OO995_RS07090 (NUITMVS2_13700) 1598745..1599167 - 423 WP_069455294.1 type II toxin-antitoxin system antitoxin Antitoxin
OO995_RS07095 (NUITMVS2_13710) 1599274..1600041 - 768 WP_086904479.1 HutD family protein -
OO995_RS07100 (NUITMVS2_13720) 1600317..1600763 - 447 WP_181159904.1 copper resistance protein NlpE -
OO995_RS07105 (NUITMVS2_13730) 1601154..1602515 + 1362 WP_109277866.1 GAF domain-containing sensor histidine kinase -
OO995_RS07110 (NUITMVS2_13740) 1602659..1603549 + 891 WP_055646646.1 glucose-1-phosphate thymidylyltransferase RfbA -
OO995_RS07115 (NUITMVS2_13750) 1603536..1604078 + 543 WP_037428279.1 dTDP-4-dehydrorhamnose 3,5-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15296.57 Da        Isoelectric Point: 6.3185

>T42631 WP_069455295.1 NZ_AP026732:c1598752-1598351 [Shewanella xiamenensis]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

>T42631 NZ_AP026732:c1598752-1598351 [Shewanella xiamenensis]
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGAAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCGCAGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGCAGTACATGACTACCAAGAACT
CAACCTTGATATCGTTGTCCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15795.88 Da        Isoelectric Point: 5.1520

>AT42631 WP_069455294.1 NZ_AP026732:c1599167-1598745 [Shewanella xiamenensis]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Download         Length: 423 bp

>AT42631 NZ_AP026732:c1599167-1598745 [Shewanella xiamenensis]
ATGCAACAACTAAATGAAAAGAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACA
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGACC
ATAGGGGGAGTCACTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252EQR5

Antitoxin

Source ID Structure
AlphaFold DB A0A501X4H4

References