Detailed information of TA system TA042630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1534974..1535566
• Replicon: chromosome
• Accession: NZ_AP026732
• Organism: Shewanella xiamenensis strain NUITM-VS2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: OO995_RS06825
• Protein ID: WP_088585326.1
• Coordinates: 1535312..1535566 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A252ENK1
• Locus tag: OO995_RS06820
• Protein ID: WP_014610929.1
• Coordinates: 1534974..1535315 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OO995_RS06790 (NUITMVS2_13080)	1530048..1530773	+	726	WP_146193326.1	HipA domain-containing protein	-
OO995_RS06795 (NUITMVS2_13090)	1530787..1531881	-	1095	WP_083243992.1	RNA-guided endonuclease TnpB family protein	-
OO995_RS06800 (NUITMVS2_13100)	1531928..1532332	+	405	WP_069453179.1	IS200/IS605 family transposase	-
OO995_RS06805	1532412..1532711	+	300	Protein_1308	CcdB family protein	-
OO995_RS06810 (NUITMVS2_13110)	1533066..1534433	+	1368	WP_014610930.1	HipA domain-containing protein	-
OO995_RS06815 (NUITMVS2_13120)	1534430..1534810	+	381	WP_086904820.1	helix-turn-helix transcriptional regulator	-
OO995_RS06820 (NUITMVS2_13130)	1534974..1535315	-	342	WP_014610929.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OO995_RS06825 (NUITMVS2_13140)	1535312..1535566	-	255	WP_088585326.1	type II toxin-antitoxin system HicA family toxin	Toxin
OO995_RS06830	1535778..1536927	+	1150	Protein_1313	IS3-like element ISShes1 family transposase	-
OO995_RS06835 (NUITMVS2_13180)	1536958..1537509	+	552	Protein_1314	GDP-mannose 4,6-dehydratase	-
OO995_RS06840 (NUITMVS2_13190)	1537575..1537757	+	183	Protein_1315	tyrosine-type recombinase/integrase	-
OO995_RS06845 (NUITMVS2_13200)	1537835..1537999	-	165	WP_014610884.1	hypothetical protein	-
OO995_RS06850 (NUITMVS2_13210)	1538021..1538746	-	726	WP_088585328.1	zeta toxin family protein	-
OO995_RS06855 (NUITMVS2_13220)	1538820..1539986	-	1167	WP_069453175.1	DUF3596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1530787..1556720	25933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9525.05 Da
• Isoelectric Point: 10.1453

>T42630 WP_088585326.1 NZ_AP026732:c1535566-1535312 [Shewanella xiamenensis]
MNKKHLRTLTAIFARPISGTIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVISIKKWLERN
GVKA

Nucleotide

• Length: 255 bp

>T42630 NZ_AP026732:c1535566-1535312 [Shewanella xiamenensis]
ATGAACAAAAAACATTTAAGAACGTTGACGGCTATCTTTGCTAGGCCTATCAGCGGAACTATCAAGTGGTCTGATATTGA
AGCGCTGTTTATTGCTCTAGGGGCTGACATTGAAGAGCGTGAGGGGTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACATCCTCAGAAAGAAACTGACAAAGACGCAGTGATAAGCATCAAAAAATGGTTAGAAAGGAAC
GGGGTGAAAGCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12379.91 Da
• Isoelectric Point: 4.3992

>AT42630 WP_014610929.1 NZ_AP026732:c1535315-1534974 [Shewanella xiamenensis]
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA

Nucleotide

• Length: 342 bp

>AT42630 NZ_AP026732:c1535315-1534974 [Shewanella xiamenensis]
ATGAAAAATCTTATGATGATCAACGGGGTAAAAGCCTTTATTGATTATGATCCAGACGCTGAAACATTCCGTGGTGAGTT
CGTAGGCTTAAACGGCGGCGCGGATTTCTATGGTGAAAGCGTCGCTCAATTGGAAGCCGAGGGCGCGAAGTCATTAAGCG
TTTTTTTAGAGATGTGTCAGGAGCGTGGCATTGAGCCTTACAAAAACTTCTCTGGCAAATTCAACGTTCGGATCTCGCCA
GAGGTTCACGCTCGACTTAATGAAATTGCGCTATCGCAAAGCATTAGTTTGAATGCAGCGGTAGAAAATGCAGTCAATGA
CTACATTGCACATTCAGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A252ENK1