Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 2692882..2693577 Replicon chromosome
Accession NZ_AP026721
Organism Enterococcus faecalis strain SVR2330

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag PO855_RS13395 Protein ID WP_002367289.1
Coordinates 2693233..2693577 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag PO855_RS13390 Protein ID WP_172494175.1
Coordinates 2692882..2693214 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO855_RS13325 (2688116) 2688116..2689132 - 1017 WP_271528272.1 RecT family recombinase -
PO855_RS13330 (2689225) 2689225..2689581 - 357 WP_010776099.1 hypothetical protein -
PO855_RS13335 (2689584) 2689584..2689808 - 225 WP_002367281.1 hypothetical protein -
PO855_RS13340 (2689805) 2689805..2690104 - 300 WP_172494173.1 hypothetical protein -
PO855_RS13345 (2690171) 2690171..2690350 - 180 WP_270781652.1 hypothetical protein -
PO855_RS13350 (2690385) 2690385..2690654 - 270 WP_002365131.1 hypothetical protein -
PO855_RS13355 (2690730) 2690730..2691044 + 315 WP_002385638.1 hypothetical protein -
PO855_RS13360 (2691025) 2691025..2691153 - 129 WP_002385637.1 hypothetical protein -
PO855_RS13365 (2691169) 2691169..2691345 - 177 WP_002385636.1 helix-turn-helix transcriptional regulator -
PO855_RS13370 (2691429) 2691429..2691812 + 384 WP_002385635.1 DUF2513 domain-containing protein -
PO855_RS13375 (2691809) 2691809..2692018 - 210 WP_271528289.1 DUF2829 domain-containing protein -
PO855_RS13380 (2692051) 2692051..2692389 - 339 WP_010829958.1 hypothetical protein -
PO855_RS13385 (2692402) 2692402..2692584 - 183 WP_002358110.1 hypothetical protein -
PO855_RS13390 (2692882) 2692882..2693214 + 333 WP_172494175.1 helix-turn-helix transcriptional regulator Antitoxin
PO855_RS13395 (2693233) 2693233..2693577 + 345 WP_002367289.1 ImmA/IrrE family metallo-endopeptidase Toxin
PO855_RS13400 (2693606) 2693606..2694004 + 399 WP_010706860.1 hypothetical protein -
PO855_RS13405 (2694022) 2694022..2694744 + 723 WP_172494176.1 potassium channel family protein -
PO855_RS13410 (2694899) 2694899..2696080 + 1182 WP_172494177.1 site-specific integrase -
PO855_RS13415 (2696183) 2696183..2696332 - 150 WP_002356321.1 50S ribosomal protein L33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2661424..2696080 34656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13668.65 Da        Isoelectric Point: 5.2241

>T42615 WP_002367289.1 NZ_AP026721:2693233-2693577 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMELYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

>T42615 NZ_AP026721:2693233-2693577 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAGTTAAAGC
ATGTAAAAGACCATGTGGATATAATGGAATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAATCCGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAATTTATTTGAAGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12733.34 Da        Isoelectric Point: 5.2423

>AT42615 WP_172494175.1 NZ_AP026721:2692882-2693214 [Enterococcus faecalis]
MNTYEIIKELTKRKKMSIRQLEITLGYSNGYFSKWKKVSPNSEGLQKVADYFNVSVDYLLGRTDNTKATDEKISDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT42615 NZ_AP026721:2692882-2693214 [Enterococcus faecalis]
ATGAATACTTATGAAATAATAAAAGAGTTGACAAAAAGGAAGAAAATGTCTATTCGACAATTAGAAATTACTCTAGGTTA
CTCAAATGGATATTTTAGCAAGTGGAAAAAAGTTTCTCCAAACTCAGAAGGCCTACAAAAAGTTGCGGACTACTTCAATG
TATCGGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAATTTCTGATGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCACTTGATGATCATGACAGAGAAGTTATTCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References