42611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 419147..419681 Replicon chromosome
Accession NZ_AP026721
Organism Enterococcus faecalis strain SVR2330

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag PO855_RS02150 Protein ID WP_002360769.1
Coordinates 419406..419681 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag PO855_RS02145 Protein ID WP_002369771.1
Coordinates 419147..419413 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO855_RS02110 (415197) 415197..415790 + 594 WP_002414802.1 replication-relaxation family protein -
PO855_RS02115 (415796) 415796..416284 + 489 WP_010710133.1 hypothetical protein -
PO855_RS02120 (416876) 416876..417142 + 267 WP_002377947.1 hypothetical protein -
PO855_RS02125 (417175) 417175..417675 + 501 WP_002360775.1 DnaJ domain-containing protein -
PO855_RS02130 (417688) 417688..417936 + 249 WP_002360773.1 DUF3850 domain-containing protein -
PO855_RS02135 (418012) 418012..418428 + 417 WP_010710134.1 single-stranded DNA-binding protein -
PO855_RS02140 (418452) 418452..419036 + 585 WP_002377949.1 thermonuclease family protein -
PO855_RS02145 (419147) 419147..419413 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PO855_RS02150 (419406) 419406..419681 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
PO855_RS02155 (419872) 419872..420516 - 645 WP_002377952.1 IS6 family transposase -
PO855_RS02160 (420740) 420740..421714 + 975 WP_002355428.1 choloylglycine hydrolase -
PO855_RS02165 (422383) 422383..422991 - 609 Protein_402 IS6 family transposase -
PO855_RS02170 (423023) 423023..423208 - 186 WP_002358660.1 hypothetical protein -
PO855_RS02175 (423238) 423238..423567 + 330 WP_002358661.1 LPXTG cell wall anchor domain-containing protein -
PO855_RS02180 (423695) 423695..424633 + 939 WP_002370935.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - EF0485 / bsh / cylR2 / cylR1 / cylL / cylS / cylM / cylB / cylB / cylA / cylI / esp / psaA 388487..518304 129817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T42611 WP_002360769.1 NZ_AP026721:419406-419681 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

>T42611 NZ_AP026721:419406-419681 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT42611 WP_002369771.1 NZ_AP026721:419147-419413 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp

>AT42611 NZ_AP026721:419147-419413 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References