Detailed information of TA system TA042608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-ParD
• Location: 1682161..1682708
• Replicon: chromosome
• Accession: NZ_AP026710
• Organism: Cutibacterium granulosum strain TP-CG7 isolate Human

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: TPCG7_RS07220
• Protein ID: WP_231933760.1
• Coordinates: 1682161..1682478 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: U1EU05
• Locus tag: TPCG7_RS07225
• Protein ID: WP_021104869.1
• Coordinates: 1682475..1682708 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TPCG7_RS07215 (TPCG7_14180)	1678399..1681881	-	3483	WP_286319263.1	DNA-directed RNA polymerase subunit beta	-
TPCG7_RS07220 (TPCG7_14190)	1682161..1682478	-	318	WP_231933760.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
TPCG7_RS07225 (TPCG7_14200)	1682475..1682708	-	234	WP_021104869.1	ribbon-helix-helix domain-containing protein	Antitoxin
TPCG7_RS07230 (TPCG7_14210)	1682943..1683338	-	396	WP_023034352.1	50S ribosomal protein L7/L12	-
TPCG7_RS07235 (TPCG7_14220)	1683352..1683963	-	612	WP_023034353.1	50S ribosomal protein L10	-
TPCG7_RS07240 (TPCG7_14230)	1684396..1685094	-	699	WP_021104866.1	50S ribosomal protein L1	-
TPCG7_RS07245 (TPCG7_14240)	1685181..1685612	-	432	WP_021104865.1	50S ribosomal protein L11	-
TPCG7_RS07250 (TPCG7_14250)	1685875..1686807	-	933	WP_286319281.1	transcription termination/antitermination protein NusG	-
TPCG7_RS07255 (TPCG7_14260)	1686833..1687483	-	651	WP_036902775.1	preprotein translocase subunit SecE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (11-93)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11508.57 Da
• Isoelectric Point: 8.5380

>T42608 WP_231933760.1 NZ_AP026710:c1682478-1682161 [Cutibacterium granulosum]
MIMREICLARMDRTRPVVVLTREVSRQAMTKVTVAPVTSTIKGLCSEVRVGKANGLDHESAIALDNVLTIPVDRLGRSIG
FLTPDQEKALARAFVMAYDLELPVA

Nucleotide

• Length: 318 bp

>T42608 NZ_AP026710:c1682478-1682161 [Cutibacterium granulosum]
ATGATCATGCGTGAGATCTGTCTGGCTCGGATGGACAGGACTCGACCCGTTGTCGTCCTCACCCGTGAAGTGTCCCGTCA
GGCAATGACCAAGGTCACCGTTGCTCCAGTCACGTCGACCATCAAGGGGCTGTGCAGCGAGGTACGCGTCGGCAAGGCCA
ACGGTCTTGACCATGAGTCCGCGATTGCCCTGGACAATGTGTTGACGATCCCGGTGGATCGGCTCGGCCGAAGTATTGGT
TTTCTCACCCCGGATCAGGAGAAGGCTCTTGCCCGTGCCTTCGTCATGGCATATGACCTTGAGCTTCCAGTGGCCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8420.50 Da
• Isoelectric Point: 4.1473

>AT42608 WP_021104869.1 NZ_AP026710:c1682708-1682475 [Cutibacterium granulosum]
MTTQISVRLPDEMVSFLDRCVSEGRVASRAEIIAGAVEREMRREAAMRDAAILAEVGSADDLDDLVAWSVEHPEMGS

Nucleotide

• Length: 234 bp

>AT42608 NZ_AP026710:c1682708-1682475 [Cutibacterium granulosum]
ATGACGACACAGATCTCGGTTCGGCTTCCTGATGAGATGGTCTCCTTCCTTGATCGCTGTGTGTCCGAGGGGCGCGTTGC
CAGCCGTGCTGAGATCATCGCTGGAGCGGTGGAGCGTGAGATGCGTCGTGAAGCGGCGATGCGTGATGCAGCCATCCTCG
CCGAGGTCGGATCTGCAGATGATTTGGATGATCTTGTGGCATGGTCGGTGGAGCACCCGGAGATGGGGTCATGA

Structures

Antitoxin

• AlphaFold DB: U1EU05