42601

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 279035..279597 Replicon plasmid pN9T4-1
Accession NZ_AP026692
Organism Rhodococcus qingshengii strain N9T-4

Toxin (Protein)


Gene name relE Uniprot ID A0A3G9A8R6
Locus tag OQH86_RS31785 Protein ID WP_054828169.1
Coordinates 279035..279325 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3G9A8Q8
Locus tag OQH86_RS31790 Protein ID WP_054828168.1
Coordinates 279322..279597 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH86_RS31760 (RQN9TF_31970) 274243..274527 - 285 WP_125053390.1 helix-turn-helix transcriptional regulator -
OQH86_RS31765 (RQN9TF_31975) 274524..275603 - 1080 WP_075835920.1 tyrosine-type recombinase/integrase -
OQH86_RS31770 (RQN9TF_31980) 275728..276015 - 288 WP_125053392.1 glutaredoxin-like protein NrdH -
OQH86_RS31775 (RQN9TF_31985) 276626..277618 + 993 WP_125053394.1 DUF2971 domain-containing protein -
OQH86_RS31780 (RQN9TF_31990) 277615..278898 + 1284 WP_265155258.1 IS256 family transposase -
OQH86_RS31785 (RQN9TF_31995) 279035..279325 - 291 WP_054828169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OQH86_RS31790 (RQN9TF_32000) 279322..279597 - 276 WP_054828168.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQH86_RS31795 (RQN9TF_32005) 280104..281168 - 1065 WP_125053398.1 AAA family ATPase -
OQH86_RS31800 (RQN9TF_32010) 281294..282331 + 1038 WP_125053400.1 aliphatic amidase -
OQH86_RS31805 (RQN9TF_32015) 282491..283570 + 1080 WP_054828167.1 substrate-binding domain-containing protein -
OQH86_RS31810 (RQN9TF_32020) 283594..284088 - 495 WP_265155259.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..565206 565206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(14-94)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10949.34 Da        Isoelectric Point: 7.5715

>T42601 WP_054828169.1 NZ_AP026692:c279325-279035 [Rhodococcus qingshengii]
MSDAPTDSSDPYRVEVASPARRDLQRLPSRIVHAVIEFISGPLAENPHRLSKPLRDDLDGLHSARRGDYRILLHIDDPNH
TIVIVRIDHRAHAYRT

Download         Length: 291 bp

>T42601 NZ_AP026692:c279325-279035 [Rhodococcus qingshengii]
ATGAGCGACGCTCCCACAGACTCGTCCGACCCGTACCGGGTCGAAGTCGCATCCCCAGCTCGCCGCGACCTTCAACGTCT
CCCATCCCGGATCGTCCACGCCGTCATCGAATTCATCTCCGGACCCCTCGCCGAGAACCCTCACCGGCTCAGCAAACCGC
TACGCGACGACCTCGACGGTCTCCACAGCGCCCGCCGCGGCGACTACCGAATCCTGCTCCACATCGACGACCCCAACCAC
ACCATCGTCATCGTCAGAATCGACCACCGTGCCCACGCCTATCGCACCTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9694.82 Da        Isoelectric Point: 4.6221

>AT42601 WP_054828168.1 NZ_AP026692:c279597-279322 [Rhodococcus qingshengii]
MTTVPLGEAKDKLSALVDSAETTHDIITITKHGKPAAVLMSADDLESLHETIYWLSRAGVRDDVATADAEYAAGHTASID
DLRAEHGLPPK

Download         Length: 276 bp

>AT42601 NZ_AP026692:c279597-279322 [Rhodococcus qingshengii]
ATGACGACAGTGCCACTGGGTGAAGCCAAGGACAAGCTCTCCGCGCTGGTCGATAGCGCCGAAACCACGCACGACATCAT
CACGATCACCAAGCACGGCAAACCCGCCGCGGTGCTGATGTCTGCCGACGACCTCGAATCGCTGCACGAGACGATCTACT
GGCTCTCACGTGCCGGTGTCCGCGACGACGTCGCTACCGCCGACGCCGAGTACGCTGCCGGCCACACTGCCTCCATCGAC
GACCTGCGCGCGGAACACGGCCTGCCGCCGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9A8R6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9A8Q8

References