Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4180998..4181779 Replicon chromosome
Accession NZ_AP026680
Organism Salmonella enterica subsp. enterica serovar Oranienburg strain 11548

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag QMM99_RS20440 Protein ID WP_000625912.1
Coordinates 4180998..4181489 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag QMM99_RS20445 Protein ID WP_001110450.1
Coordinates 4181486..4181779 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM99_RS20415 (4176129) 4176129..4178567 - 2439 WP_023215132.1 F4 (K88) fimbrial usher FaeD -
QMM99_RS20420 (4178577) 4178577..4179116 - 540 WP_000721295.1 type 1 fimbrial protein -
QMM99_RS20425 (4179151) 4179151..4179441 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
QMM99_RS20430 (4180028) 4180028..4180285 + 258 WP_001112996.1 hypothetical protein -
QMM99_RS20435 (4180530) 4180530..4180763 - 234 Protein_3994 IS481 family transposase -
QMM99_RS20440 (4180998) 4180998..4181489 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
QMM99_RS20445 (4181486) 4181486..4181779 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
QMM99_RS20450 (4182097) 4182097..4182319 + 223 Protein_3997 hypothetical protein -
QMM99_RS20455 (4182583) 4182583..4183458 + 876 WP_000921676.1 AraC family transcriptional regulator -
QMM99_RS20460 (4183455) 4183455..4183742 + 288 WP_001269916.1 transcriptional regulator RtsB -
QMM99_RS20465 (4183735) 4183735..4183917 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
QMM99_RS20470 (4183937) 4183937..4184036 + 100 Protein_4001 hypothetical protein -
QMM99_RS20475 (4184146) 4184146..4184280 + 135 Protein_4002 hypothetical protein -
QMM99_RS20480 (4184575) 4184575..4185480 - 906 WP_001268201.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4168707..4183917 15210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T42596 WP_000625912.1 NZ_AP026680:c4181489-4180998 [Salmonella enterica subsp. enterica serovar Oranienburg]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T42596 NZ_AP026680:c4181489-4180998 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGATTTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCAC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT42596 WP_001110450.1 NZ_AP026680:c4181779-4181486 [Salmonella enterica subsp. enterica serovar Oranienburg]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT42596 NZ_AP026680:c4181779-4181486 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TAGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References