Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4065106..4065622 Replicon chromosome
Accession NZ_AP026680
Organism Salmonella enterica subsp. enterica serovar Oranienburg strain 11548

Toxin (Protein)


Gene name relE Uniprot ID A0A3V8UX29
Locus tag QMM99_RS19800 Protein ID WP_023215156.1
Coordinates 4065106..4065390 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I1C3W3
Locus tag QMM99_RS19805 Protein ID WP_000212722.1
Coordinates 4065380..4065622 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM99_RS19785 (4060222) 4060222..4061874 + 1653 WP_023215157.1 alpha,alpha-phosphotrehalase -
QMM99_RS19790 (4062283) 4062283..4064421 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
QMM99_RS19795 (4064638) 4064638..4065102 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QMM99_RS19800 (4065106) 4065106..4065390 - 285 WP_023215156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMM99_RS19805 (4065380) 4065380..4065622 - 243 WP_000212722.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QMM99_RS19810 (4065700) 4065700..4067613 - 1914 WP_023215155.1 BglG family transcription antiterminator -
QMM99_RS19815 (4067630) 4067630..4068370 - 741 WP_000779254.1 KDGP aldolase family protein -
QMM99_RS19820 (4068367) 4068367..4069485 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QMM99_RS19825 (4069469) 4069469..4070602 - 1134 WP_023215154.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10882.72 Da        Isoelectric Point: 10.0482

>T42595 WP_023215156.1 NZ_AP026680:c4065390-4065106 [Salmonella enterica subsp. enterica serovar Oranienburg]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSVRLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T42595 NZ_AP026680:c4065390-4065106 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGTCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8988.37 Da        Isoelectric Point: 5.0651

>AT42595 WP_000212722.1 NZ_AP026680:c4065622-4065380 [Salmonella enterica subsp. enterica serovar Oranienburg]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDNEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT42595 NZ_AP026680:c4065622-4065380 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACTGTCACTCTTAGCGACA
ATGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8UX29

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1C3W3

References