Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3385954..3386574 Replicon chromosome
Accession NZ_AP026680
Organism Salmonella enterica subsp. enterica serovar Oranienburg strain 11548

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QMM99_RS16690 Protein ID WP_001280991.1
Coordinates 3386356..3386574 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QMM99_RS16685 Protein ID WP_000344807.1
Coordinates 3385954..3386328 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM99_RS16675 (3381093) 3381093..3382286 + 1194 WP_023214889.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QMM99_RS16680 (3382309) 3382309..3385458 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QMM99_RS16685 (3385954) 3385954..3386328 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QMM99_RS16690 (3386356) 3386356..3386574 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QMM99_RS16695 (3386753) 3386753..3387304 + 552 WP_001278791.1 maltose O-acetyltransferase -
QMM99_RS16700 (3387422) 3387422..3387892 + 471 WP_000136183.1 YlaC family protein -
QMM99_RS16705 (3387948) 3387948..3388088 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QMM99_RS16710 (3388090) 3388090..3388353 - 264 WP_000801416.1 type B 50S ribosomal protein L31 -
QMM99_RS16715 (3388578) 3388578..3390128 + 1551 WP_023215340.1 EAL domain-containing protein -
QMM99_RS16725 (3390359) 3390359..3390748 + 390 WP_000961285.1 MGMT family protein -
QMM99_RS16730 (3390781) 3390781..3391350 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T42591 WP_001280991.1 NZ_AP026680:3386356-3386574 [Salmonella enterica subsp. enterica serovar Oranienburg]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T42591 NZ_AP026680:3386356-3386574 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT42591 WP_000344807.1 NZ_AP026680:3385954-3386328 [Salmonella enterica subsp. enterica serovar Oranienburg]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT42591 NZ_AP026680:3385954-3386328 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References