Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811348..812008 Replicon chromosome
Accession NZ_AP026680
Organism Salmonella enterica subsp. enterica serovar Oranienburg strain 11548

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag QMM99_RS03910 Protein ID WP_000244757.1
Coordinates 811595..812008 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag QMM99_RS03905 Protein ID WP_000351186.1
Coordinates 811348..811614 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM99_RS03885 (807276) 807276..808709 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
QMM99_RS03890 (808868) 808868..809179 + 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
QMM99_RS03895 (809343) 809343..810002 + 660 WP_000250289.1 hemolysin III family protein -
QMM99_RS03900 (810118) 810118..811098 - 981 WP_023214406.1 tRNA-modifying protein YgfZ -
QMM99_RS03905 (811348) 811348..811614 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
QMM99_RS03910 (811595) 811595..812008 + 414 WP_000244757.1 protein YgfX Toxin
QMM99_RS03915 (812061) 812061..812582 - 522 WP_001055885.1 flavodoxin FldB -
QMM99_RS03920 (812695) 812695..813591 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
QMM99_RS03925 (813615) 813615..814328 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QMM99_RS03930 (814334) 814334..816067 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T42582 WP_000244757.1 NZ_AP026680:811595-812008 [Salmonella enterica subsp. enterica serovar Oranienburg]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T42582 NZ_AP026680:811595-812008 [Salmonella enterica subsp. enterica serovar Oranienburg]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT42582 WP_000351186.1 NZ_AP026680:811348-811614 [Salmonella enterica subsp. enterica serovar Oranienburg]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42582 NZ_AP026680:811348-811614 [Salmonella enterica subsp. enterica serovar Oranienburg]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References