Detailed information of TA system TA042579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 5331..5841
• Replicon: chromosome
• Accession: NZ_AP026671
• Organism: Nitratiruptor tergarcus DSM 16512

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: NITER_RS00040
• Protein ID: WP_084274682.1
• Coordinates: 5331..5603 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: NITER_RS00045
• Protein ID: WP_197685259.1
• Coordinates: 5584..5841 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NITER_RS00010	412..738	+	327	WP_084274689.1	UPF0175 family protein	-
NITER_RS00015	735..1190	+	456	WP_084274688.1	DUF3368 domain-containing protein	-
NITER_RS00020	1310..2770	-	1461	WP_084274687.1	GNAT family N-acetyltransferase	-
NITER_RS00025	2760..3959	-	1200	WP_084274686.1	M20 family metallopeptidase	-
NITER_RS00030	4528..4710	+	183	WP_084274684.1	hypothetical protein	-
NITER_RS00035	4695..5009	+	315	WP_084274683.1	hypothetical protein	-
NITER_RS00040	5331..5603	+	273	WP_084274682.1	BrnT family toxin	Toxin
NITER_RS00045	5584..5841	+	258	WP_197685259.1	CopG family antitoxin	Antitoxin
NITER_RS00050	6746..6946	+	201	WP_084274681.1	hypothetical protein	-
NITER_RS00060	7190..8371	-	1182	WP_084274680.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
NITER_RS00065	8371..9435	-	1065	WP_084274679.1	phospho-N-acetylmuramoyl-pentapeptide- transferase	-
NITER_RS00070	9513..10256	+	744	WP_084274678.1	3-oxoacyl-ACP reductase FabG	-
NITER_RS00075	10313..10549	+	237	WP_084274677.1	acyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• CopG antitoxin (10-75)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10630.87 Da
• Isoelectric Point: 5.2340

>T42579 WP_084274682.1 NZ_AP026671:5331-5603 [Nitratiruptor tergarcus DSM 16512]
VHIEYDPNKSKANKQKHGLDFEEARELFENDDSLIVPAKIIDGEERYALIGYLDGKCYVAIFTYRGENIRIISVRRCRKN
EERNYEEYNG

Nucleotide

• Length: 273 bp

>T42579 NZ_AP026671:5331-5603 [Nitratiruptor tergarcus DSM 16512]
GTGCATATCGAATACGATCCAAACAAAAGTAAAGCCAATAAGCAAAAGCATGGCTTAGACTTTGAGGAGGCTAGAGAGCT
CTTTGAAAATGACGACTCACTCATCGTGCCAGCCAAGATTATTGATGGCGAGGAGCGATATGCGCTTATCGGCTATCTCG
ATGGCAAGTGCTATGTGGCAATATTCACCTATAGAGGTGAAAATATCAGGATCATAAGTGTGAGAAGATGTAGAAAAAAC
GAGGAGAGAAACTATGAAGAGTATAACGGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9784.38 Da
• Isoelectric Point: 8.5043

>AT42579 WP_197685259.1 NZ_AP026671:5584-5841 [Nitratiruptor tergarcus DSM 16512]
MKSITAKEFDEKFDRGEDISEYLDFGKAKRVGEVKKQPTKKINIDLPQNILNLIDEEASKIGVARQALLKVWIVERLKEE
LSKPL

Nucleotide

• Length: 258 bp

>AT42579 NZ_AP026671:5584-5841 [Nitratiruptor tergarcus DSM 16512]
ATGAAGAGTATAACGGCTAAAGAGTTTGATGAGAAGTTTGATAGAGGCGAAGATATAAGTGAGTATCTTGATTTTGGTAA
GGCTAAAAGAGTAGGAGAAGTTAAAAAGCAGCCTACCAAAAAGATAAATATCGACCTACCTCAAAACATCCTCAATCTCA
TCGATGAGGAAGCAAGTAAAATAGGAGTGGCAAGGCAGGCACTGCTGAAAGTGTGGATAGTGGAGAGGCTCAAAGAGGAA
CTATCCAAGCCATTGTGA