Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2626585..2627114 Replicon chromosome
Accession NZ_AP026666
Organism Enterococcus faecium strain GK961

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag OQH70_RS13410 Protein ID WP_002296560.1
Coordinates 2626585..2626851 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag OQH70_RS13415 Protein ID WP_002296559.1
Coordinates 2626851..2627114 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH70_RS13385 (EfmGK961_26240) 2621953..2623128 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
OQH70_RS13390 (EfmGK961_26250) 2623132..2623773 + 642 WP_002293405.1 ABC transporter permease -
OQH70_RS13395 (EfmGK961_26260) 2623770..2624687 + 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
OQH70_RS13400 (EfmGK961_26270) 2624702..2625355 + 654 WP_002323018.1 ABC transporter permease -
OQH70_RS13405 (EfmGK961_26280) 2625896..2626384 - 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
OQH70_RS13410 (EfmGK961_26290) 2626585..2626851 - 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
OQH70_RS13415 (EfmGK961_26300) 2626851..2627114 - 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQH70_RS13420 (EfmGK961_26310) 2627590..2627775 + 186 WP_002296558.1 transcriptional regulator -
OQH70_RS13425 (EfmGK961_26320) 2627917..2629740 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T42577 WP_002296560.1 NZ_AP026666:c2626851-2626585 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T42577 NZ_AP026666:c2626851-2626585 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT42577 WP_002296559.1 NZ_AP026666:c2627114-2626851 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT42577 NZ_AP026666:c2627114-2626851 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References