Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 2625691..2626220 | Replicon | chromosome |
Accession | NZ_AP026660 | ||
Organism | Enterococcus faecium strain GK941 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q3XX67 |
Locus tag | OQH75_RS13270 | Protein ID | WP_002296560.1 |
Coordinates | 2625691..2625957 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A829F3T0 |
Locus tag | OQH75_RS13275 | Protein ID | WP_002296559.1 |
Coordinates | 2625957..2626220 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OQH75_RS13245 (EfmGK941_26180) | 2621059..2622234 | + | 1176 | WP_002294192.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
OQH75_RS13250 (EfmGK941_26190) | 2622238..2622879 | + | 642 | WP_002293405.1 | ABC transporter permease | - |
OQH75_RS13255 (EfmGK941_26200) | 2622876..2623793 | + | 918 | WP_002302664.1 | osmoprotectant ABC transporter substrate-binding protein | - |
OQH75_RS13260 (EfmGK941_26210) | 2623808..2624461 | + | 654 | WP_002323018.1 | ABC transporter permease | - |
OQH75_RS13265 (EfmGK941_26220) | 2625002..2625490 | - | 489 | WP_002296561.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
OQH75_RS13270 (EfmGK941_26230) | 2625691..2625957 | - | 267 | WP_002296560.1 | Txe/YoeB family addiction module toxin | Toxin |
OQH75_RS13275 (EfmGK941_26240) | 2625957..2626220 | - | 264 | WP_002296559.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
OQH75_RS13280 (EfmGK941_26250) | 2626697..2626882 | + | 186 | WP_002296558.1 | transcriptional regulator | - |
OQH75_RS13285 (EfmGK941_26260) | 2627024..2628847 | - | 1824 | WP_002294202.1 | APC family permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10660.13 Da Isoelectric Point: 9.9931
>T42572 WP_002296560.1 NZ_AP026660:c2625957-2625691 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T42572 NZ_AP026660:c2625957-2625691 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10046.05 Da Isoelectric Point: 4.1207
>AT42572 WP_002296559.1 NZ_AP026660:c2626220-2625957 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
Download Length: 264 bp
>AT42572 NZ_AP026660:c2626220-2625957 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FCW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F3T0 |