Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 1426935..1427454 Replicon chromosome
Accession NZ_AP026660
Organism Enterococcus faecium strain GK941

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag OQH75_RS07300 Protein ID WP_000588503.1
Coordinates 1427197..1427454 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag OQH75_RS07295 Protein ID WP_000388479.1
Coordinates 1426935..1427204 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH75_RS07245 (EfmGK941_14240) 1422132..1423031 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
OQH75_RS07250 (EfmGK941_14250) 1423034..1423519 + 486 WP_002303313.1 single-stranded DNA-binding protein -
OQH75_RS07255 1423660..1423764 - 105 WP_008274030.1 putative holin-like toxin -
OQH75_RS07260 (EfmGK941_14260) 1423938..1424198 + 261 WP_002295623.1 hypothetical protein -
OQH75_RS07265 (EfmGK941_14270) 1424635..1424841 + 207 WP_002347218.1 hypothetical protein -
OQH75_RS07270 (EfmGK941_14280) 1424841..1425092 + 252 WP_002296238.1 hypothetical protein -
OQH75_RS07275 (EfmGK941_14290) 1425107..1425544 + 438 WP_002300851.1 hypothetical protein -
OQH75_RS07280 (EfmGK941_14300) 1425537..1426244 + 708 WP_002303117.1 hypothetical protein -
OQH75_RS07285 (EfmGK941_14310) 1426409..1426609 + 201 WP_002347143.1 hypothetical protein -
OQH75_RS07290 (EfmGK941_14320) 1426625..1426804 + 180 WP_001120991.1 hypothetical protein -
OQH75_RS07295 (EfmGK941_14330) 1426935..1427204 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQH75_RS07300 (EfmGK941_14340) 1427197..1427454 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
OQH75_RS07305 (EfmGK941_14350) 1428092..1428910 + 819 WP_265145707.1 HEPN domain-containing protein -
OQH75_RS07310 (EfmGK941_14360) 1429081..1429695 - 615 WP_001261742.1 recombinase family protein -
OQH75_RS07315 (EfmGK941_14370) 1429755..1429969 + 215 Protein_1410 hypothetical protein -
OQH75_RS07320 (EfmGK941_14380) 1430365..1430568 + 204 WP_002299573.1 hypothetical protein -
OQH75_RS07325 (EfmGK941_14390) 1430779..1431363 + 585 WP_002299575.1 recombinase family protein -
OQH75_RS07330 (EfmGK941_14400) 1431734..1432381 + 648 Protein_1413 type VI secretion protein ImpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / aph(3')-III / tet(M) ebpC / srtC 1321022..1470447 149425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T42570 WP_000588503.1 NZ_AP026660:1427197-1427454 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T42570 NZ_AP026660:1427197-1427454 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT42570 WP_000388479.1 NZ_AP026660:1426935-1427204 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT42570 NZ_AP026660:1426935-1427204 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References