Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 1426935..1427454 | Replicon | chromosome |
Accession | NZ_AP026660 | ||
Organism | Enterococcus faecium strain GK941 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | OQH75_RS07300 | Protein ID | WP_000588503.1 |
Coordinates | 1427197..1427454 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | OQH75_RS07295 | Protein ID | WP_000388479.1 |
Coordinates | 1426935..1427204 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OQH75_RS07245 (EfmGK941_14240) | 1422132..1423031 | + | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
OQH75_RS07250 (EfmGK941_14250) | 1423034..1423519 | + | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
OQH75_RS07255 | 1423660..1423764 | - | 105 | WP_008274030.1 | putative holin-like toxin | - |
OQH75_RS07260 (EfmGK941_14260) | 1423938..1424198 | + | 261 | WP_002295623.1 | hypothetical protein | - |
OQH75_RS07265 (EfmGK941_14270) | 1424635..1424841 | + | 207 | WP_002347218.1 | hypothetical protein | - |
OQH75_RS07270 (EfmGK941_14280) | 1424841..1425092 | + | 252 | WP_002296238.1 | hypothetical protein | - |
OQH75_RS07275 (EfmGK941_14290) | 1425107..1425544 | + | 438 | WP_002300851.1 | hypothetical protein | - |
OQH75_RS07280 (EfmGK941_14300) | 1425537..1426244 | + | 708 | WP_002303117.1 | hypothetical protein | - |
OQH75_RS07285 (EfmGK941_14310) | 1426409..1426609 | + | 201 | WP_002347143.1 | hypothetical protein | - |
OQH75_RS07290 (EfmGK941_14320) | 1426625..1426804 | + | 180 | WP_001120991.1 | hypothetical protein | - |
OQH75_RS07295 (EfmGK941_14330) | 1426935..1427204 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
OQH75_RS07300 (EfmGK941_14340) | 1427197..1427454 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
OQH75_RS07305 (EfmGK941_14350) | 1428092..1428910 | + | 819 | WP_265145707.1 | HEPN domain-containing protein | - |
OQH75_RS07310 (EfmGK941_14360) | 1429081..1429695 | - | 615 | WP_001261742.1 | recombinase family protein | - |
OQH75_RS07315 (EfmGK941_14370) | 1429755..1429969 | + | 215 | Protein_1410 | hypothetical protein | - |
OQH75_RS07320 (EfmGK941_14380) | 1430365..1430568 | + | 204 | WP_002299573.1 | hypothetical protein | - |
OQH75_RS07325 (EfmGK941_14390) | 1430779..1431363 | + | 585 | WP_002299575.1 | recombinase family protein | - |
OQH75_RS07330 (EfmGK941_14400) | 1431734..1432381 | + | 648 | Protein_1413 | type VI secretion protein ImpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | erm(B) / aph(3')-III / tet(M) | ebpC / srtC | 1321022..1470447 | 149425 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T42570 WP_000588503.1 NZ_AP026660:1427197-1427454 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T42570 NZ_AP026660:1427197-1427454 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT42570 WP_000388479.1 NZ_AP026660:1426935-1427204 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT42570 NZ_AP026660:1426935-1427204 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |