Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 1424153..1424672 Replicon chromosome
Accession NZ_AP026655
Organism Enterococcus faecium strain GK923

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag OQH82_RS07280 Protein ID WP_000588503.1
Coordinates 1424415..1424672 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag OQH82_RS07275 Protein ID WP_000388479.1
Coordinates 1424153..1424422 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH82_RS07225 (EfmGK923_13980) 1419350..1420249 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
OQH82_RS07230 (EfmGK923_13990) 1420252..1420737 + 486 WP_002303313.1 single-stranded DNA-binding protein -
OQH82_RS07235 1420878..1420982 - 105 WP_008274030.1 putative holin-like toxin -
OQH82_RS07240 (EfmGK923_14000) 1421156..1421416 + 261 WP_002295623.1 hypothetical protein -
OQH82_RS07245 (EfmGK923_14010) 1421853..1422059 + 207 WP_002347218.1 hypothetical protein -
OQH82_RS07250 (EfmGK923_14020) 1422059..1422310 + 252 WP_002296238.1 hypothetical protein -
OQH82_RS07255 (EfmGK923_14030) 1422325..1422762 + 438 WP_002300851.1 hypothetical protein -
OQH82_RS07260 (EfmGK923_14040) 1422755..1423462 + 708 WP_002303117.1 hypothetical protein -
OQH82_RS07265 (EfmGK923_14050) 1423627..1423827 + 201 WP_002347143.1 hypothetical protein -
OQH82_RS07270 (EfmGK923_14060) 1423843..1424022 + 180 WP_001120991.1 hypothetical protein -
OQH82_RS07275 (EfmGK923_14070) 1424153..1424422 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQH82_RS07280 (EfmGK923_14080) 1424415..1424672 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
OQH82_RS07285 (EfmGK923_14100) 1425309..1426133 + 825 WP_265169765.1 hypothetical protein -
OQH82_RS07290 (EfmGK923_14110) 1426298..1426912 - 615 WP_001261742.1 recombinase family protein -
OQH82_RS07295 (EfmGK923_14120) 1427150..1427572 + 423 WP_002303116.1 hypothetical protein -
OQH82_RS07300 1427716..1427808 - 93 Protein_1407 DDE-type integrase/transposase/recombinase -
OQH82_RS07305 (EfmGK923_14130) 1427993..1428577 + 585 WP_002299575.1 recombinase family protein -
OQH82_RS07310 (EfmGK923_14140) 1428948..1429595 + 648 Protein_1409 type VI secretion protein ImpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / aph(3')-III / tet(M) ebpC / srtC 1318222..1467660 149438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T42565 WP_000588503.1 NZ_AP026655:1424415-1424672 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T42565 NZ_AP026655:1424415-1424672 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT42565 WP_000388479.1 NZ_AP026655:1424153-1424422 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT42565 NZ_AP026655:1424153-1424422 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References