Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
| Location | 94444..94963 | Replicon | plasmid pAA94_1 |
| Accession | NZ_AP026613 | ||
| Organism | Enterococcus faecium strain AA94 | ||
Toxin (Protein)
| Gene name | Txe | Uniprot ID | Q848U6 |
| Locus tag | OQH77_RS14735 | Protein ID | WP_000588503.1 |
| Coordinates | 94706..94963 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | Axe | Uniprot ID | Q83WJ8 |
| Locus tag | OQH77_RS14730 | Protein ID | WP_000388479.1 |
| Coordinates | 94444..94713 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OQH77_RS14680 (EfmAA94_28920) | 89641..90540 | + | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| OQH77_RS14685 (EfmAA94_28930) | 90543..91028 | + | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
| OQH77_RS14690 | 91169..91273 | - | 105 | WP_008274030.1 | putative holin-like toxin | - |
| OQH77_RS14695 (EfmAA94_28940) | 91447..91707 | + | 261 | WP_002295623.1 | hypothetical protein | - |
| OQH77_RS14700 (EfmAA94_28950) | 92144..92350 | + | 207 | WP_002347218.1 | hypothetical protein | - |
| OQH77_RS14705 (EfmAA94_28960) | 92350..92601 | + | 252 | WP_002296238.1 | hypothetical protein | - |
| OQH77_RS14710 (EfmAA94_28970) | 92616..93053 | + | 438 | WP_002300851.1 | hypothetical protein | - |
| OQH77_RS14715 (EfmAA94_28980) | 93046..93753 | + | 708 | WP_002303117.1 | hypothetical protein | - |
| OQH77_RS14720 (EfmAA94_28990) | 93918..94118 | + | 201 | WP_002347143.1 | hypothetical protein | - |
| OQH77_RS14725 (EfmAA94_29000) | 94134..94313 | + | 180 | WP_001120991.1 | hypothetical protein | - |
| OQH77_RS14730 (EfmAA94_29010) | 94444..94713 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OQH77_RS14735 (EfmAA94_29020) | 94706..94963 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
| OQH77_RS14740 (EfmAA94_29030) | 95606..95989 | + | 384 | WP_265161960.1 | hypothetical protein | - |
| OQH77_RS14745 (EfmAA94_29050) | 96138..96344 | + | 207 | WP_265161961.1 | hypothetical protein | - |
| OQH77_RS14750 (EfmAA94_29060) | 96586..97200 | - | 615 | WP_001261742.1 | recombinase family protein | - |
| OQH77_RS14755 (EfmAA94_29080) | 97870..98073 | + | 204 | WP_265161962.1 | hypothetical protein | - |
| OQH77_RS14760 (EfmAA94_29090) | 98284..98868 | + | 585 | WP_265161963.1 | recombinase family protein | - |
| OQH77_RS14765 | 99030..99709 | - | 680 | Protein_112 | IS6 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | VanHBX / ant(6)-Ia / erm(B) | - | 1..321364 | 321364 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T42562 WP_000588503.1 NZ_AP026613:94706-94963 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T42562 NZ_AP026613:94706-94963 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT42562 WP_000388479.1 NZ_AP026613:94444-94713 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT42562 NZ_AP026613:94444-94713 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZXQ8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZWU7 |