Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 218698..219227 Replicon chromosome
Accession NZ_AP026612
Organism Enterococcus faecium strain AA94

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag OQH77_RS01095 Protein ID WP_002296560.1
Coordinates 218961..219227 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag OQH77_RS01090 Protein ID WP_002296559.1
Coordinates 218698..218961 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH77_RS01080 (EfmAA94_02150) 216072..217895 + 1824 WP_002294202.1 APC family permease -
OQH77_RS01085 (EfmAA94_02160) 218037..218222 - 186 WP_002296558.1 transcriptional regulator -
OQH77_RS01090 (EfmAA94_02170) 218698..218961 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQH77_RS01095 (EfmAA94_02180) 218961..219227 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
OQH77_RS01100 (EfmAA94_02190) 219428..219916 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
OQH77_RS01105 (EfmAA94_02200) 220457..221110 - 654 WP_002323018.1 ABC transporter permease -
OQH77_RS01110 (EfmAA94_02210) 221125..222042 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
OQH77_RS01115 (EfmAA94_02220) 222039..222680 - 642 WP_002293405.1 ABC transporter permease -
OQH77_RS01120 (EfmAA94_02230) 222684..223265 - 582 Protein_223 CBS domain-containing protein -
OQH77_RS01125 (EfmAA94_02240) 223423..223827 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T42559 WP_002296560.1 NZ_AP026612:218961-219227 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T42559 NZ_AP026612:218961-219227 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT42559 WP_002296559.1 NZ_AP026612:218698-218961 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT42559 NZ_AP026612:218698-218961 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References