Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 197210..197739 | Replicon | chromosome |
Accession | NZ_AP026566 | ||
Organism | Enterococcus faecium strain JHP9 |
Toxin (Protein)
Gene name | relE | Uniprot ID | C9B8W9 |
Locus tag | OQH78_RS00975 | Protein ID | WP_002294198.1 |
Coordinates | 197473..197739 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A1S8JTG2 |
Locus tag | OQH78_RS00970 | Protein ID | WP_002317080.1 |
Coordinates | 197210..197473 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OQH78_RS00960 (EfmJHP9_01950) | 194585..196408 | + | 1824 | WP_002294202.1 | APC family permease | - |
OQH78_RS00965 (EfmJHP9_01960) | 196550..196735 | - | 186 | WP_002294201.1 | hypothetical protein | - |
OQH78_RS00970 (EfmJHP9_01970) | 197210..197473 | + | 264 | WP_002317080.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
OQH78_RS00975 (EfmJHP9_01980) | 197473..197739 | + | 267 | WP_002294198.1 | Txe/YoeB family addiction module toxin | Toxin |
OQH78_RS00980 (EfmJHP9_01990) | 197940..198428 | + | 489 | WP_002301120.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
OQH78_RS00985 (EfmJHP9_02000) | 198970..199623 | - | 654 | WP_002317081.1 | ABC transporter permease | - |
OQH78_RS00990 (EfmJHP9_02010) | 199638..200555 | - | 918 | WP_002301114.1 | osmoprotectant ABC transporter substrate-binding protein | - |
OQH78_RS00995 (EfmJHP9_02020) | 200552..201193 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
OQH78_RS01000 (EfmJHP9_02030) | 201197..202372 | - | 1176 | WP_002317082.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10646.11 Da Isoelectric Point: 9.9931
>T42548 WP_002294198.1 NZ_AP026566:197473-197739 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T42548 NZ_AP026566:197473-197739 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCACCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCACCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10015.04 Da Isoelectric Point: 4.1844
>AT42548 WP_002317080.1 NZ_AP026566:197210-197473 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL
Download Length: 264 bp
>AT42548 NZ_AP026566:197210-197473 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
AATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
AATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FMA0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1S8JTG2 |