Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 197210..197739 Replicon chromosome
Accession NZ_AP026566
Organism Enterococcus faecium strain JHP9

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag OQH78_RS00975 Protein ID WP_002294198.1
Coordinates 197473..197739 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S8JTG2
Locus tag OQH78_RS00970 Protein ID WP_002317080.1
Coordinates 197210..197473 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQH78_RS00960 (EfmJHP9_01950) 194585..196408 + 1824 WP_002294202.1 APC family permease -
OQH78_RS00965 (EfmJHP9_01960) 196550..196735 - 186 WP_002294201.1 hypothetical protein -
OQH78_RS00970 (EfmJHP9_01970) 197210..197473 + 264 WP_002317080.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OQH78_RS00975 (EfmJHP9_01980) 197473..197739 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
OQH78_RS00980 (EfmJHP9_01990) 197940..198428 + 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
OQH78_RS00985 (EfmJHP9_02000) 198970..199623 - 654 WP_002317081.1 ABC transporter permease -
OQH78_RS00990 (EfmJHP9_02010) 199638..200555 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
OQH78_RS00995 (EfmJHP9_02020) 200552..201193 - 642 WP_002293405.1 ABC transporter permease -
OQH78_RS01000 (EfmJHP9_02030) 201197..202372 - 1176 WP_002317082.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T42548 WP_002294198.1 NZ_AP026566:197473-197739 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T42548 NZ_AP026566:197473-197739 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCACCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.04 Da        Isoelectric Point: 4.1844

>AT42548 WP_002317080.1 NZ_AP026566:197210-197473 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL

Download         Length: 264 bp

>AT42548 NZ_AP026566:197210-197473 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
AATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8JTG2

References