Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2689582..2690157 Replicon chromosome
Accession NZ_AP026560
Organism Deinococcus aetherius strain ST0316

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DAETH_RS13735 Protein ID WP_264775441.1
Coordinates 2689582..2689851 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DAETH_RS13740 Protein ID WP_264775442.1
Coordinates 2689936..2690157 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAETH_RS13705 (DAETH_27210) 2684986..2686221 - 1236 WP_264775435.1 argininosuccinate synthase -
DAETH_RS13710 (DAETH_27220) 2686511..2686984 - 474 WP_264775436.1 hypothetical protein -
DAETH_RS13715 (DAETH_27230) 2687038..2688162 - 1125 WP_264775437.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
DAETH_RS13720 (DAETH_27240) 2688334..2688948 + 615 WP_264775438.1 LysE/ArgO family amino acid transporter -
DAETH_RS13725 (DAETH_27250) 2688937..2689263 - 327 WP_264775439.1 PIN domain-containing protein -
DAETH_RS13730 (DAETH_27260) 2689263..2689511 - 249 WP_264775440.1 hypothetical protein -
DAETH_RS13735 (DAETH_27270) 2689582..2689851 - 270 WP_264775441.1 DUF5615 family PIN-like protein Toxin
DAETH_RS13740 (DAETH_27280) 2689936..2690157 - 222 WP_264775442.1 DUF433 domain-containing protein Antitoxin
DAETH_RS13745 (DAETH_27290) 2690294..2691265 - 972 WP_264775443.1 hypothetical protein -
DAETH_RS13750 (DAETH_27300) 2691370..2694441 + 3072 WP_264775444.1 carbamoyl-phosphate synthase large subunit -
DAETH_RS13755 (DAETH_27310) 2694565..2694807 + 243 WP_264775445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2688937..2700834 11897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(3-56)

Antitoxin

Protein of unknown function DUF433

(7-61)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9860.23 Da        Isoelectric Point: 5.5967

>T42547 WP_264775441.1 NZ_AP026560:c2689851-2689582 [Deinococcus aetherius]
VEAYSVAYLGYREAEDEVIFQAARAVSAVVVSKDADFLERLVRLGPPPQLLYVTCGNTSKARLVEIFGRHFEHAHRLLSS
GEPIVEITS

Download         Length: 270 bp

>T42547 NZ_AP026560:c2689851-2689582 [Deinococcus aetherius]
GTGGAGGCGTACAGCGTGGCGTACCTGGGCTACCGGGAGGCGGAGGACGAAGTGATTTTTCAGGCGGCGCGGGCTGTAAG
CGCAGTGGTGGTGTCCAAGGATGCCGACTTCCTTGAGCGGCTGGTACGCCTCGGCCCCCCGCCACAACTGCTGTATGTGA
CCTGTGGAAATACGAGCAAAGCGCGACTGGTAGAGATTTTTGGTCGGCATTTTGAGCATGCCCATAGGCTGCTCTCGTCC
GGCGAGCCCATTGTTGAAATCACTTCGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8197.46 Da        Isoelectric Point: 4.4702

>AT42547 WP_264775442.1 NZ_AP026560:c2690157-2689936 [Deinococcus aetherius]
MTLLDRITVNPLQCGGRPCIRGMRIRVSDVLDLLGAGVEVDEILSDYPDLEREDIYAALIWAARYVDHPRLSA

Download         Length: 222 bp

>AT42547 NZ_AP026560:c2690157-2689936 [Deinococcus aetherius]
ATGACCCTACTCGACCGTATCACCGTGAACCCCTTGCAGTGCGGCGGACGCCCCTGTATCCGGGGGATGCGGATTCGGGT
GAGTGACGTGCTGGACCTGCTCGGCGCAGGGGTCGAGGTGGATGAAATCTTGAGCGACTACCCGGACCTGGAGCGCGAGG
ACATTTACGCCGCGCTGATCTGGGCTGCCCGGTACGTTGACCATCCCCGACTGAGTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References