Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1933134..1933775 Replicon chromosome
Accession NZ_AP026560
Organism Deinococcus aetherius strain ST0316

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DAETH_RS09670 Protein ID WP_264774691.1
Coordinates 1933134..1933535 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DAETH_RS09675 Protein ID WP_264774692.1
Coordinates 1933536..1933775 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAETH_RS09650 (DAETH_19390) 1929173..1929952 + 780 WP_264774688.1 YkgJ family cysteine cluster protein -
DAETH_RS09655 (DAETH_19400) 1930021..1930875 + 855 WP_264774689.1 sugar phosphate isomerase/epimerase -
DAETH_RS09660 (DAETH_19410) 1930923..1932083 + 1161 WP_264777423.1 diaminopimelate decarboxylase -
DAETH_RS09665 (DAETH_19420) 1932123..1933097 + 975 WP_264774690.1 nuclease-related domain-containing protein -
DAETH_RS09670 (DAETH_19430) 1933134..1933535 - 402 WP_264774691.1 type II toxin-antitoxin system VapC family toxin Toxin
DAETH_RS09675 (DAETH_19440) 1933536..1933775 - 240 WP_264774692.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DAETH_RS09680 (DAETH_19450) 1933920..1934570 + 651 WP_264774693.1 TetR/AcrR family transcriptional regulator -
DAETH_RS09685 (DAETH_19460) 1934709..1935476 + 768 WP_264774694.1 TerC family protein -
DAETH_RS09690 (DAETH_19470) 1935678..1936475 - 798 WP_264774695.1 endonuclease III -
DAETH_RS09695 (DAETH_19480) 1936533..1937105 - 573 WP_264774696.1 hypothetical protein -
DAETH_RS09700 (DAETH_19490) 1937182..1938372 + 1191 WP_264777424.1 ATP phosphoribosyltransferase regulatory subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

SpoVT-AbrB domain

(7-40)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14784.05 Da        Isoelectric Point: 6.4685

>T42546 WP_264774691.1 NZ_AP026560:c1933535-1933134 [Deinococcus aetherius]
MALQFLLDTNICIYVMNRRPPQVAKRFAEFPPDAIGLSSLTLAELSYGVEKSGSERNRVVLEGFVQPLEVVAFDPVAARQ
YGVVRSTLERRGTPIGALDTLIAAHALALGLTLVTHNTREFERVEGLRVENWF

Download         Length: 402 bp

>T42546 NZ_AP026560:c1933535-1933134 [Deinococcus aetherius]
ATGGCCCTGCAATTCCTGCTCGACACCAATATCTGTATCTACGTCATGAACCGCCGTCCTCCGCAGGTGGCCAAACGGTT
CGCCGAGTTCCCACCGGACGCCATTGGTCTGTCCAGCCTGACGCTCGCCGAGTTGAGCTATGGGGTCGAGAAAAGCGGGT
CCGAGCGGAACCGCGTGGTGCTGGAAGGCTTCGTTCAGCCGCTCGAAGTCGTCGCCTTCGATCCTGTCGCCGCCCGGCAG
TACGGCGTGGTGAGGAGCACCCTGGAACGCAGGGGAACGCCCATCGGCGCGCTGGACACGCTGATCGCGGCCCACGCCCT
GGCCCTCGGCCTGACCCTTGTCACCCACAACACCCGCGAATTCGAGCGGGTCGAGGGGCTCAGGGTCGAGAACTGGTTTT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9283.46 Da        Isoelectric Point: 8.6861

>AT42546 WP_264774692.1 NZ_AP026560:c1933775-1933536 [Deinococcus aetherius]
VTTAKLFRNGRSQAVRLPKAFQFEGQEVVVKRVGNGVLLLPSSPEGQREFWRRWYQELPEMETAIERNQPPAQERDWDQ

Download         Length: 240 bp

>AT42546 NZ_AP026560:c1933775-1933536 [Deinococcus aetherius]
GTGACCACTGCGAAACTGTTCAGGAATGGCCGCAGTCAGGCTGTCCGCCTGCCCAAAGCTTTCCAGTTCGAGGGCCAGGA
GGTCGTCGTGAAAAGGGTTGGAAACGGTGTCCTGCTGCTACCGTCCTCGCCCGAGGGGCAGCGCGAGTTCTGGCGCCGTT
GGTATCAGGAACTCCCGGAGATGGAGACGGCCATTGAGCGGAACCAACCTCCCGCCCAGGAACGCGACTGGGACCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References