Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1142240..1142916 Replicon chromosome
Accession NZ_AP026560
Organism Deinococcus aetherius strain ST0316

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DAETH_RS05775 Protein ID WP_264776967.1
Coordinates 1142485..1142916 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DAETH_RS05770 Protein ID WP_264776966.1
Coordinates 1142240..1142485 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAETH_RS05745 (DAETH_11470) 1138090..1139223 - 1134 WP_264776962.1 WD40 repeat domain-containing protein -
DAETH_RS05750 (DAETH_11480) 1139348..1139767 + 420 WP_264776963.1 cobalamin B12-binding domain-containing protein -
DAETH_RS05755 (DAETH_11490) 1139769..1140953 + 1185 WP_264776964.1 MFS transporter -
DAETH_RS05760 (DAETH_11500) 1141027..1141818 - 792 WP_264776965.1 MHYT domain-containing protein -
DAETH_RS05770 1142240..1142485 + 246 WP_264776966.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DAETH_RS05775 (DAETH_11510) 1142485..1142916 + 432 WP_264776967.1 type II toxin-antitoxin system VapC family toxin Toxin
DAETH_RS05790 (DAETH_11530) 1143865..1144404 - 540 WP_264776968.1 DUF402 domain-containing protein -
DAETH_RS05795 (DAETH_11540) 1144413..1144997 - 585 WP_264776969.1 phosphoribosylglycinamide formyltransferase -
DAETH_RS05800 (DAETH_11550) 1145092..1146471 - 1380 WP_264776970.1 dipeptidase -
DAETH_RS05805 (DAETH_11560) 1146856..1147656 + 801 WP_264776971.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-62)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15525.80 Da        Isoelectric Point: 7.1677

>T42545 WP_264776967.1 NZ_AP026560:1142485-1142916 [Deinococcus aetherius]
MFLLDTNVVSERSRPQPDERVLSWLRTHKVGETYLSVITLAELEQGIIRLGSTKRAAELRAFLGGVEVQFAGRVLSIDRA
VARTWTSMTAGAIAAGRPPGYADSLIAATALTHGLTVVTRNIPDFEAVLGCDRLVNPWEAPNP

Download         Length: 432 bp

>T42545 NZ_AP026560:1142485-1142916 [Deinococcus aetherius]
ATGTTCCTCCTCGACACGAACGTCGTCAGCGAACGCAGCCGTCCCCAGCCCGACGAGCGCGTTCTTTCTTGGCTCCGAAC
GCATAAGGTCGGGGAGACGTACCTCAGCGTCATCACCCTGGCCGAGTTGGAGCAGGGAATCATCCGACTTGGGAGCACCA
AGCGGGCGGCGGAACTGCGGGCGTTTCTTGGTGGCGTAGAAGTGCAGTTTGCGGGGAGGGTCCTGAGCATCGACCGGGCG
GTAGCGCGAACCTGGACGAGCATGACGGCTGGGGCCATCGCGGCGGGCAGGCCACCGGGCTACGCGGACTCGCTGATCGC
CGCGACCGCCCTCACGCACGGCCTGACCGTCGTAACACGGAACATCCCGGACTTCGAGGCGGTGCTTGGCTGTGACCGTC
TCGTGAATCCCTGGGAAGCGCCCAACCCTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9045.30 Da        Isoelectric Point: 4.8549

>AT42545 WP_264776966.1 NZ_AP026560:1142240-1142485 [Deinococcus aetherius]
MKEAWQLQEAKAHFSELVEAALQKGPQTVTRRGEKAVVVLAHSEFMRLTQAEKTLDEALSGAPEELVFERDRTPVPAVTL
E

Download         Length: 246 bp

>AT42545 NZ_AP026560:1142240-1142485 [Deinococcus aetherius]
ATGAAGGAAGCTTGGCAACTTCAGGAGGCGAAAGCGCACTTCAGCGAATTGGTGGAGGCTGCCTTGCAGAAGGGACCACA
GACCGTGACGAGGCGCGGCGAGAAGGCTGTGGTGGTGCTGGCCCACAGTGAATTTATGCGACTGACTCAGGCAGAGAAGA
CGTTGGATGAGGCGCTGAGCGGAGCGCCGGAAGAACTCGTCTTTGAGCGTGACCGTACGCCCGTTCCTGCGGTCACATTG
GAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References