Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 348998..349566 Replicon chromosome
Accession NZ_AP026560
Organism Deinococcus aetherius strain ST0316

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DAETH_RS01760 Protein ID WP_264776235.1
Coordinates 349210..349566 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DAETH_RS01755 Protein ID WP_264776234.1
Coordinates 348998..349213 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAETH_RS01730 (DAETH_03350) 344417..345067 + 651 WP_264776229.1 tRNA (guanosine(18)-2'-O)-methyltransferase TrmH -
DAETH_RS01735 (DAETH_03360) 345236..346030 + 795 WP_264776230.1 TerC family protein -
DAETH_RS01740 (DAETH_03370) 346145..346963 + 819 WP_264776231.1 TerC family protein -
DAETH_RS01745 (DAETH_03380) 347061..348305 + 1245 WP_264776232.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
DAETH_RS01750 (DAETH_03390) 348363..348893 - 531 WP_264776233.1 ATP-binding protein -
DAETH_RS01755 (DAETH_03400) 348998..349213 + 216 WP_264776234.1 ribbon-helix-helix domain-containing protein Antitoxin
DAETH_RS01760 (DAETH_03410) 349210..349566 + 357 WP_264776235.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DAETH_RS01765 (DAETH_03420) 349595..350146 - 552 WP_264776236.1 GNAT family N-acetyltransferase -
DAETH_RS01770 (DAETH_03430) 350137..350493 - 357 WP_264776237.1 hypothetical protein -
DAETH_RS01775 (DAETH_03440) 350715..353165 + 2451 WP_264776238.1 transglycosylase domain-containing protein -
DAETH_RS01780 (DAETH_03450) 353228..354199 - 972 WP_264776239.1 phosphotriesterase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13048.60 Da        Isoelectric Point: 6.8822

>T42544 WP_264776235.1 NZ_AP026560:349210-349566 [Deinococcus aetherius]
VSSGEEPLRRGDLVLVDLDPAVSSEANKTRPAVVVSNDRANRTSPVVTVVPVTSNTAHVYSFQVYLAREESGLDHDSKAQ
AEQVRSLDRRRVRRHLGALPSERLDQLDAALRLHLTLE

Download         Length: 357 bp

>T42544 NZ_AP026560:349210-349566 [Deinococcus aetherius]
GTGAGTTCGGGCGAGGAGCCCTTGCGGCGGGGCGATCTCGTCCTTGTCGATCTCGATCCGGCGGTGAGCAGCGAGGCGAA
CAAGACCCGGCCCGCCGTCGTGGTGAGTAACGACCGGGCCAACCGCACCTCGCCGGTGGTGACGGTCGTTCCCGTGACCA
GCAACACCGCGCACGTCTACTCCTTTCAGGTGTACCTCGCGCGGGAGGAGAGCGGGCTGGACCACGACAGCAAGGCCCAG
GCCGAGCAGGTCAGAAGTCTCGACCGTCGCCGGGTCCGGCGGCACCTCGGCGCCCTGCCTTCCGAACGCCTGGACCAACT
CGACGCCGCCCTCAGGCTCCACCTCACCCTGGAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8194.15 Da        Isoelectric Point: 4.6104

>AT42544 WP_264776234.1 NZ_AP026560:348998-349213 [Deinococcus aetherius]
VKLSVSLPEPQIDFLDHYQRRHRLGSRSEVVQMALKLLQERALEEEYRAAGEEWQGSEDAVLWDRVSGDGL

Download         Length: 216 bp

>AT42544 NZ_AP026560:348998-349213 [Deinococcus aetherius]
GTGAAGCTGAGCGTGAGTCTCCCCGAGCCTCAGATCGATTTTCTGGACCACTATCAGCGCCGCCACCGTCTCGGCAGCCG
CAGCGAGGTGGTGCAGATGGCCTTGAAGCTGCTTCAGGAGCGTGCCCTGGAGGAGGAGTACCGCGCGGCGGGCGAGGAAT
GGCAGGGCAGCGAGGACGCCGTGCTGTGGGACCGTGTGAGTGGGGACGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References