Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1485771..1486299 Replicon chromosome
Accession NZ_AP026552
Organism Vibrio vulnificus strain VV20-8B-2 isolate homogenised shrimp

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag OO986_RS06835 Protein ID WP_005377002.1
Coordinates 1485771..1486061 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag OO986_RS06840 Protein ID WP_005377003.1
Coordinates 1486051..1486299 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO986_RS06790 (VV208B2_12680) 1481018..1481434 + 417 WP_264922590.1 VOC family protein -
OO986_RS06795 1481452..1481541 + 90 WP_072615218.1 DUF3265 domain-containing protein -
OO986_RS06800 (VV208B2_12690) 1481579..1482304 + 726 WP_039470383.1 NYN domain-containing protein -
OO986_RS06805 1482319..1482412 + 94 Protein_1283 DUF3265 domain-containing protein -
OO986_RS06810 (VV208B2_12700) 1482454..1483032 + 579 WP_039444437.1 hypothetical protein -
OO986_RS06815 1483485..1483610 + 126 WP_071919811.1 DUF3265 domain-containing protein -
OO986_RS06820 1484029..1484158 + 130 Protein_1286 DUF3265 domain-containing protein -
OO986_RS06825 (VV208B2_12710) 1484203..1484841 + 639 WP_264922597.1 glutathione S-transferase -
OO986_RS06830 (VV208B2_12720) 1484992..1485642 + 651 WP_171933932.1 hypothetical protein -
OO986_RS06835 (VV208B2_12730) 1485771..1486061 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO986_RS06840 (VV208B2_12740) 1486051..1486299 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OO986_RS06845 1486374..1486442 + 69 WP_074531725.1 DUF3265 domain-containing protein -
OO986_RS06850 (VV208B2_12750) 1486492..1486839 + 348 WP_264922599.1 hypothetical protein -
OO986_RS06855 (VV208B2_12760) 1487032..1487772 + 741 WP_108695209.1 FRG domain-containing protein -
OO986_RS06860 (VV208B2_12770) 1487775..1488950 + 1176 WP_108695208.1 DUF262 domain-containing protein -
OO986_RS06865 1488965..1489057 + 93 WP_072600976.1 DUF3265 domain-containing protein -
OO986_RS06870 1489888..1490037 + 150 WP_108695169.1 DUF3265 domain-containing protein -
OO986_RS06875 (VV208B2_12780) 1490034..1490540 + 507 WP_108695168.1 hypothetical protein -
OO986_RS06880 1490527..1490682 + 156 WP_108695172.1 DUF3265 domain-containing protein -
OO986_RS06885 (VV208B2_12790) 1490737..1491060 + 324 WP_264922606.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1460130..1549030 88900
- inside Integron - - 1460130..1541709 81579


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T42538 WP_005377002.1 NZ_AP026552:c1486061-1485771 [Vibrio vulnificus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T42538 NZ_AP026552:c1486061-1485771 [Vibrio vulnificus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTAATCATTGTAACCGTCCTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT42538 WP_005377003.1 NZ_AP026552:c1486299-1486051 [Vibrio vulnificus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT42538 NZ_AP026552:c1486299-1486051 [Vibrio vulnificus]
ATGACCACTAGAATTTTAGCTGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References