Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4682566..4683082 Replicon chromosome
Accession NZ_AP026525
Organism Klebsiella pneumoniae subsp. pneumoniae strain TUM9839

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OO859_RS22775 Protein ID WP_004178374.1
Coordinates 4682566..4682850 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OO859_RS22780 Protein ID WP_002886901.1
Coordinates 4682840..4683082 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO859_RS22750 (TUM9839_43850) 4678050..4678313 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
OO859_RS22755 4678443..4678616 + 174 WP_032408826.1 hypothetical protein -
OO859_RS22760 (TUM9839_43860) 4678619..4679362 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OO859_RS22765 (TUM9839_43870) 4679719..4681857 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OO859_RS22770 (TUM9839_43880) 4682098..4682562 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OO859_RS22775 (TUM9839_43890) 4682566..4682850 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO859_RS22780 (TUM9839_43900) 4682840..4683082 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OO859_RS22785 (TUM9839_43910) 4683160..4685070 - 1911 WP_135630353.1 PRD domain-containing protein -
OO859_RS22790 (TUM9839_43920) 4685093..4686247 - 1155 WP_032437541.1 lactonase family protein -
OO859_RS22795 (TUM9839_43930) 4686314..4687054 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T42534 WP_004178374.1 NZ_AP026525:c4682850-4682566 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T42534 NZ_AP026525:c4682850-4682566 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT42534 WP_002886901.1 NZ_AP026525:c4683082-4682840 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT42534 NZ_AP026525:c4683082-4682840 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References