42518

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1049343..1049967 Replicon chromosome
Accession NZ_AP026446
Organism Helicobacter pylori strain CHC155

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OW489_RS04970 Protein ID WP_245065742.1
Coordinates 1049343..1049609 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OW489_RS04975 Protein ID WP_267285855.1
Coordinates 1049590..1049967 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OW489_RS04950 (CHC155_09830) 1045992..1046759 - 768 WP_000242367.1 ABC transporter ATP-binding protein -
OW489_RS04955 (CHC155_09840) 1046759..1047739 - 981 WP_000921438.1 iron ABC transporter permease -
OW489_RS04960 (CHC155_09850) 1047732..1048574 - 843 WP_180415663.1 SDR family oxidoreductase -
OW489_RS04965 (CHC155_09860) 1048715..1049239 + 525 WP_060758828.1 acyl-CoA thioesterase -
OW489_RS04970 (CHC155_09870) 1049343..1049609 - 267 WP_245065742.1 type II toxin-antitoxin system YafQ family toxin Toxin
OW489_RS04975 (CHC155_09880) 1049590..1049967 - 378 WP_267285855.1 hypothetical protein Antitoxin
OW489_RS04980 (CHC155_09890) 1050242..1052476 - 2235 WP_267285856.1 Hop family adhesin BabA -
OW489_RS04995 (CHC155_09900) 1052890..1053533 + 644 Protein_981 hypothetical protein -
OW489_RS05000 (CHC155_09910) 1053484..1054596 - 1113 WP_267285857.1 hydrogenase formation protein HypD -
OW489_RS05005 (CHC155_09920) 1054602..1054835 - 234 WP_120857459.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10330.15 Da        Isoelectric Point: 8.0602

>T42518 WP_245065742.1 NZ_AP026446:c1049609-1049343 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGNWKPFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

>T42518 NZ_AP026446:c1049609-1049343 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTAGACCCACAATTTAAAGATCATGCTTTAAAAGGCAATTGGA
AACCTTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATTTGGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14618.59 Da        Isoelectric Point: 8.4602

>AT42518 WP_267285855.1 NZ_AP026446:c1049967-1049590 [Helicobacter pylori]
MPNSPAKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNGLLQKISQAFDDKRDCCL
GRKIPNIETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQP

Download         Length: 378 bp

>AT42518 NZ_AP026446:c1049967-1049590 [Helicobacter pylori]
ATGCCTAATTCTCCTGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGGACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References