Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 105833..106358 | Replicon | plasmid pKAM645_3 |
| Accession | NZ_AP026423 | ||
| Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain KAM645 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | D4HQE7 |
| Locus tag | OCV84_RS28635 | Protein ID | WP_013023785.1 |
| Coordinates | 106053..106358 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | W8V2V6 |
| Locus tag | OCV84_RS28630 | Protein ID | WP_001568025.1 |
| Coordinates | 105833..106051 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCV84_RS28595 (KAM645c_55700) | 101530..103191 | - | 1662 | WP_033488203.1 | IS481 family transposase | - |
| OCV84_RS28600 (KAM645c_55710) | 103175..103531 | - | 357 | WP_261902534.1 | recombinase family protein | - |
| OCV84_RS28605 (KAM645c_55720) | 103541..104245 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| OCV84_RS28610 (KAM645c_55730) | 104310..104528 | - | 219 | Protein_107 | AAA family ATPase | - |
| OCV84_RS28615 (KAM645c_55740) | 104602..105018 | - | 417 | WP_016236302.1 | type II toxin-antitoxin system VapC family toxin | - |
| OCV84_RS28620 (KAM645c_55750) | 105015..105245 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| OCV84_RS28625 | 105202..105663 | + | 462 | WP_261902524.1 | hypothetical protein | - |
| OCV84_RS28630 (KAM645c_55770) | 105833..106051 | + | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| OCV84_RS28635 (KAM645c_55780) | 106053..106358 | + | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| OCV84_RS28640 (KAM645c_55790) | 106527..106922 | + | 396 | WP_017899885.1 | hypothetical protein | - |
| OCV84_RS28645 (KAM645c_55800) | 106949..107263 | + | 315 | WP_053389906.1 | hypothetical protein | - |
| OCV84_RS28650 (KAM645c_55810) | 107274..108290 | + | 1017 | WP_017899884.1 | hypothetical protein | - |
| OCV84_RS28655 (KAM645c_55820) | 108488..109282 | + | 795 | WP_004197635.1 | site-specific integrase | - |
| OCV84_RS28660 (KAM645c_55840) | 109770..110072 | - | 303 | WP_071571079.1 | hypothetical protein | - |
| OCV84_RS28665 (KAM645c_55850) | 110069..110695 | - | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..180281 | 180281 | |
| - | flank | IS/Tn | - | - | 103541..104245 | 704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T42516 WP_013023785.1 NZ_AP026423:106053-106358 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T42516 NZ_AP026423:106053-106358 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT42516 WP_001568025.1 NZ_AP026423:105833-106051 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT42516 NZ_AP026423:105833-106051 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4ZZP8 |