Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 778493..779150 Replicon chromosome
Accession NZ_AP026407
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain KAM644

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag P4I75_RS03835 Protein ID WP_023290968.1
Coordinates 778740..779150 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P4I75_RS03830 Protein ID WP_002916312.1
Coordinates 778493..778759 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4I75_RS03805 (773661) 773661..775094 - 1434 WP_023290972.1 6-phospho-beta-glucosidase BglA -
P4I75_RS03810 (775213) 775213..775941 - 729 WP_261902453.1 MurR/RpiR family transcriptional regulator -
P4I75_RS03815 (775992) 775992..776303 + 312 WP_064158016.1 N(4)-acetylcytidine aminohydrolase -
P4I75_RS03820 (776467) 776467..777129 + 663 WP_065883827.1 hemolysin III family protein -
P4I75_RS03825 (777264) 777264..778247 - 984 WP_101977706.1 tRNA-modifying protein YgfZ -
P4I75_RS03830 (778493) 778493..778759 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P4I75_RS03835 (778740) 778740..779150 + 411 WP_023290968.1 protein YgfX Toxin
P4I75_RS03840 (779157) 779157..779678 - 522 WP_004205324.1 flavodoxin FldB -
P4I75_RS03845 (779779) 779779..780675 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P4I75_RS03850 (780698) 780698..781411 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P4I75_RS03855 (781417) 781417..783150 + 1734 WP_241516354.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T42482 WP_023290968.1 NZ_AP026407:778740-779150 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T42482 NZ_AP026407:778740-779150 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT42482 WP_002916312.1 NZ_AP026407:778493-778759 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42482 NZ_AP026407:778493-778759 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAATCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References