Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 779613..780270 Replicon chromosome
Accession NZ_AP026392
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain KAM622

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag P4I30_RS03850 Protein ID WP_023290968.1
Coordinates 779860..780270 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag P4I30_RS03845 Protein ID WP_002916312.1
Coordinates 779613..779879 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4I30_RS03820 (774781) 774781..776214 - 1434 WP_023290972.1 6-phospho-beta-glucosidase BglA -
P4I30_RS03825 (776333) 776333..777061 - 729 WP_261902453.1 MurR/RpiR family transcriptional regulator -
P4I30_RS03830 (777112) 777112..777423 + 312 WP_276085602.1 N(4)-acetylcytidine aminohydrolase -
P4I30_RS03835 (777587) 777587..778249 + 663 WP_065883827.1 hemolysin III family protein -
P4I30_RS03840 (778384) 778384..779367 - 984 WP_101977706.1 tRNA-modifying protein YgfZ -
P4I30_RS03845 (779613) 779613..779879 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
P4I30_RS03850 (779860) 779860..780270 + 411 WP_023290968.1 protein YgfX Toxin
P4I30_RS03855 (780277) 780277..780798 - 522 WP_004205324.1 flavodoxin FldB -
P4I30_RS03860 (780899) 780899..781795 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
P4I30_RS03865 (781818) 781818..782531 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P4I30_RS03870 (782537) 782537..784270 + 1734 WP_241516354.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T42462 WP_023290968.1 NZ_AP026392:779860-780270 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T42462 NZ_AP026392:779860-780270 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT42462 WP_002916312.1 NZ_AP026392:779613-779879 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT42462 NZ_AP026392:779613-779879 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAATCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References