Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5186948..5187587 Replicon chromosome
Accession NZ_AP026367
Organism Mycobacterium pseudoshottsii strain NJB1907-Z4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID L7VCR2
Locus tag NJB1907Z4_RS22845 Protein ID WP_015357076.1
Coordinates 5186948..5187394 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag NJB1907Z4_RS22850 Protein ID WP_011738542.1
Coordinates 5187399..5187587 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NJB1907Z4_RS22815 (NJB1907Z4_C47140) 5182125..5183645 + 1521 WP_020786064.1 carotenoid oxygenase family protein -
NJB1907Z4_RS22820 (NJB1907Z4_C47150) 5183662..5184078 + 417 WP_020786063.1 VOC family protein -
NJB1907Z4_RS22825 (NJB1907Z4_C47160) 5184141..5184575 - 435 WP_020786062.1 hypothetical protein -
NJB1907Z4_RS22830 (NJB1907Z4_C47170) 5184646..5185418 - 773 Protein_4518 VOC family protein -
NJB1907Z4_RS22835 (NJB1907Z4_C47190) 5185839..5186312 + 474 WP_232022654.1 EspA/EspE family type VII secretion system effector -
NJB1907Z4_RS22840 (NJB1907Z4_C47200) 5186330..5186836 + 507 WP_261887869.1 hypothetical protein -
NJB1907Z4_RS22845 (NJB1907Z4_C47210) 5186948..5187394 - 447 WP_015357076.1 SRPBCC family protein Toxin
NJB1907Z4_RS22850 (NJB1907Z4_C47220) 5187399..5187587 - 189 WP_011738542.1 antitoxin Antitoxin
NJB1907Z4_RS22855 (NJB1907Z4_C47230) 5187689..5188306 - 618 WP_020786057.1 hypothetical protein -
NJB1907Z4_RS22860 (NJB1907Z4_C47240) 5188316..5189236 - 921 WP_051153625.1 PPE family protein -
NJB1907Z4_RS22865 (NJB1907Z4_C47250) 5189208..5190134 - 927 WP_261887870.1 hypothetical protein -
NJB1907Z4_RS22870 (NJB1907Z4_C47260) 5190241..5191026 - 786 WP_020786054.1 PPE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15861.43 Da        Isoelectric Point: 8.6574

>T42457 WP_015357076.1 NZ_AP026367:c5187394-5186948 [Mycobacterium pseudoshottsii]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPPAAG

Download         Length: 447 bp

>T42457 NZ_AP026367:c5187394-5186948 [Mycobacterium pseudoshottsii]
ATGGCGAAACTTTCCGGGTCGATCGACGTGCCGCTGTCTCCGGACGAGGCATGGATGCACGCATCCGATCTCTCCCGCTT
CAAGGAGTGGCTGACGATCCACCGAGTGTGGCGCAGCACGTTGCCCGAAACCCTCGAAAAGGGTGCGGTCGTCGAATCAA
TCGTGCAGGTCAAGGGCATGCACAACCGCATCAAATGGACCATCGTGCGCTACCAGCCGCCGGAAGGCATGACCCTCAAC
GGTGACGGGGTCGGCGGCGTCAAGGTCAAGCTGATGGCCAAGGTTGCAGCCGGAGAAGAAGGCTCGATCGTCAGCTTCGA
CGTGCACCTTGGTGGGCCGGCTCTGTTCGGTCCGATCGGCATGGTCGTCGCCGCGGCGCTGCGCAGCGATATCAACGCAT
CGCTGCGGAACTTCGTCACCGTATTCGCCCCGCCGGCTGCCGGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT42457 WP_011738542.1 NZ_AP026367:c5187587-5187399 [Mycobacterium pseudoshottsii]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp

>AT42457 NZ_AP026367:c5187587-5187399 [Mycobacterium pseudoshottsii]
ATGGGAATCCTGGACAAGGCGAAAGACCTGCTGGCGCAGAACGCCGACAAGGTCGAGACGGTGATCGACAAGGCCGGCGA
ATTCGTCGACGAGAAGACCGAAGGGAAGTACTCCGACACCATCCACAAGGTGCAAGAGGGGGCCAAGAAAGTCGCTGGTC
CCGGCGCCGCGGGCGAGCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XZB0

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References