Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1173557..1174035 Replicon chromosome
Accession NZ_AP026118
Organism Escherichia coli strain CEC13004

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO879_RS05425 Protein ID WP_001303876.1
Coordinates 1173557..1173844 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO879_RS05430 Protein ID WP_000536233.1
Coordinates 1173844..1174035 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO879_RS05390 (1168718) 1168718..1171189 - 2472 WP_000034474.1 exonuclease -
OO879_RS05395 (1171283) 1171283..1171474 - 192 WP_001098307.1 DUF1482 family protein -
OO879_RS05400 (1171471) 1171471..1171659 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO879_RS05405 (1172221) 1172221..1172406 + 186 WP_001133046.1 hypothetical protein -
OO879_RS05410 (1172593) 1172593..1172982 - 390 WP_000394511.1 hypothetical protein -
OO879_RS05415 (1172994) 1172994..1173122 - 129 WP_000344963.1 protein YdfB -
OO879_RS05420 (1173124) 1173124..1173279 - 156 WP_000379575.1 DUF1391 family protein -
OO879_RS05425 (1173557) 1173557..1173844 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO879_RS05430 (1173844) 1173844..1174035 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO879_RS05435 (1174063) 1174063..1174464 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO879_RS05440 (1174573) 1174573..1174845 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO879_RS05445 (1174829) 1174829..1175254 + 426 WP_000693855.1 toxin YdaT family protein -
OO879_RS05450 (1175461) 1175461..1175916 - 456 WP_000273724.1 hypothetical protein -
OO879_RS05455 (1175995) 1175995..1177086 + 1092 WP_001205823.1 hypothetical protein -
OO879_RS05460 (1177093) 1177093..1177839 + 747 WP_000788745.1 ATP-binding protein -
OO879_RS05465 (1177861) 1177861..1178631 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42422 WP_001303876.1 NZ_AP026118:c1173844-1173557 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42422 NZ_AP026118:c1173844-1173557 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42422 WP_000536233.1 NZ_AP026118:c1174035-1173844 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42422 NZ_AP026118:c1174035-1173844 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References