Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2042959..2043430 | Replicon | chromosome |
| Accession | NZ_AP026116 | ||
| Organism | Escherichia coli strain CEC13002 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO850_RS09985 | Protein ID | WP_001303511.1 |
| Coordinates | 2043152..2043430 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO850_RS09980 | Protein ID | WP_001302048.1 |
| Coordinates | 2042959..2043150 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO850_RS09940 (2038166) | 2038166..2038750 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| OO850_RS09945 (2038807) | 2038807..2039202 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO850_RS09950 (2039218) | 2039218..2039987 | - | 770 | Protein_1951 | DUF1627 domain-containing protein | - |
| OO850_RS09955 (2040013) | 2040013..2040753 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO850_RS09960 (2040760) | 2040760..2041722 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO850_RS09965 (2041745) | 2041745..2042170 | - | 426 | WP_000693944.1 | toxin YdaT family protein | - |
| OO850_RS09970 (2042167) | 2042167..2042469 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO850_RS09975 (2042567) | 2042567..2042938 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| OO850_RS09980 (2042959) | 2042959..2043150 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO850_RS09985 (2043152) | 2043152..2043430 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO850_RS09990 (2043782) | 2043782..2044081 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| OO850_RS09995 (2044193) | 2044193..2045406 | + | 1214 | WP_162829202.1 | IS3-like element IS1203 family transposase | - |
| OO850_RS10000 (2045466) | 2045466..2045684 | + | 219 | WP_001171930.1 | protein YdfC | - |
| OO850_RS10005 (2046253) | 2046253..2046441 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO850_RS10010 (2046438) | 2046438..2046629 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2001474..2049707 | 48233 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42392 WP_001303511.1 NZ_AP026116:2043152-2043430 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42392 NZ_AP026116:2043152-2043430 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42392 WP_001302048.1 NZ_AP026116:2042959-2043150 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42392 NZ_AP026116:2042959-2043150 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|