Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1166772..1167250 Replicon chromosome
Accession NZ_AP026116
Organism Escherichia coli strain CEC13002

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO850_RS05370 Protein ID WP_001303876.1
Coordinates 1166772..1167059 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO850_RS05375 Protein ID WP_000536233.1
Coordinates 1167059..1167250 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO850_RS05335 (1161921) 1161921..1164392 - 2472 WP_000034474.1 exonuclease -
OO850_RS05340 (1164486) 1164486..1164677 - 192 WP_001098307.1 DUF1482 family protein -
OO850_RS05345 (1164674) 1164674..1164862 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO850_RS05350 (1165436) 1165436..1165621 + 186 WP_001133046.1 hypothetical protein -
OO850_RS05355 (1165808) 1165808..1166197 - 390 WP_000394511.1 hypothetical protein -
OO850_RS05360 (1166209) 1166209..1166337 - 129 WP_000344963.1 protein YdfB -
OO850_RS05365 (1166339) 1166339..1166494 - 156 WP_000379575.1 DUF1391 family protein -
OO850_RS05370 (1166772) 1166772..1167059 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO850_RS05375 (1167059) 1167059..1167250 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO850_RS05380 (1167278) 1167278..1167679 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO850_RS05385 (1167788) 1167788..1168060 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO850_RS05390 (1168044) 1168044..1168469 + 426 WP_000693855.1 toxin YdaT family protein -
OO850_RS05395 (1168676) 1168676..1169131 - 456 WP_000273724.1 hypothetical protein -
OO850_RS05400 (1169210) 1169210..1170301 + 1092 WP_001205823.1 hypothetical protein -
OO850_RS05405 (1170308) 1170308..1171054 + 747 WP_000788745.1 ATP-binding protein -
OO850_RS05410 (1171076) 1171076..1171846 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42387 WP_001303876.1 NZ_AP026116:c1167059-1166772 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42387 NZ_AP026116:c1167059-1166772 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42387 WP_000536233.1 NZ_AP026116:c1167250-1167059 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42387 NZ_AP026116:c1167250-1167059 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References