Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2151906..2152544 Replicon chromosome
Accession NZ_AP026114
Organism Escherichia coli strain CEC01302

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO829_RS10625 Protein ID WP_000813794.1
Coordinates 2152368..2152544 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO829_RS10620 Protein ID WP_001270286.1
Coordinates 2151906..2152322 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO829_RS10600 (2147058) 2147058..2147999 - 942 WP_001251315.1 ABC transporter permease -
OO829_RS10605 (2148000) 2148000..2149013 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO829_RS10610 (2149031) 2149031..2150176 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO829_RS10615 (2150421) 2150421..2151827 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO829_RS10620 (2151906) 2151906..2152322 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO829_RS10625 (2152368) 2152368..2152544 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO829_RS10630 (2152766) 2152766..2152996 + 231 WP_000494244.1 YncJ family protein -
OO829_RS10635 (2153088) 2153088..2155049 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO829_RS10640 (2155122) 2155122..2155658 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO829_RS10645 (2155750) 2155750..2156923 + 1174 Protein_2085 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42365 WP_000813794.1 NZ_AP026114:c2152544-2152368 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42365 NZ_AP026114:c2152544-2152368 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42365 WP_001270286.1 NZ_AP026114:c2152322-2151906 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42365 NZ_AP026114:c2152322-2151906 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References