Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1978241..1978712 | Replicon | chromosome |
| Accession | NZ_AP026114 | ||
| Organism | Escherichia coli strain CEC01302 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO829_RS09765 | Protein ID | WP_001303511.1 |
| Coordinates | 1978241..1978519 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO829_RS09770 | Protein ID | WP_001302048.1 |
| Coordinates | 1978521..1978712 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO829_RS09735 (1973467) | 1973467..1973718 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| OO829_RS09740 (1973791) | 1973791..1976262 | - | 2472 | WP_000048458.1 | exonuclease | - |
| OO829_RS09745 (1976355) | 1976355..1976546 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO829_RS09750 (1976543) | 1976543..1976731 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO829_RS09755 (1977300) | 1977300..1977518 | - | 219 | WP_001171930.1 | protein YdfC | - |
| OO829_RS09760 (1977590) | 1977590..1977889 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| OO829_RS09765 (1978241) | 1978241..1978519 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO829_RS09770 (1978521) | 1978521..1978712 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO829_RS09775 (1978733) | 1978733..1979104 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| OO829_RS09780 (1979202) | 1979202..1979504 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO829_RS09785 (1979501) | 1979501..1979926 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO829_RS09790 (1979949) | 1979949..1980911 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO829_RS09795 (1980918) | 1980918..1981658 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO829_RS09800 (1981684) | 1981684..1982453 | + | 770 | Protein_1920 | DUF1627 domain-containing protein | - |
| OO829_RS09805 (1982469) | 1982469..1982864 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO829_RS09810 (1982921) | 1982921..1983505 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1971081..2020693 | 49612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42364 WP_001303511.1 NZ_AP026114:c1978519-1978241 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42364 NZ_AP026114:c1978519-1978241 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42364 WP_001302048.1 NZ_AP026114:c1978712-1978521 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42364 NZ_AP026114:c1978712-1978521 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|