Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1257346..1257824 Replicon chromosome
Accession NZ_AP026114
Organism Escherichia coli strain CEC01302

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO829_RS05925 Protein ID WP_001303876.1
Coordinates 1257346..1257633 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO829_RS05930 Protein ID WP_000536233.1
Coordinates 1257633..1257824 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO829_RS05890 (1252495) 1252495..1254966 - 2472 WP_000034474.1 exonuclease -
OO829_RS05895 (1255060) 1255060..1255251 - 192 WP_001098307.1 DUF1482 family protein -
OO829_RS05900 (1255248) 1255248..1255436 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO829_RS05905 (1256010) 1256010..1256195 + 186 WP_001133046.1 hypothetical protein -
OO829_RS05910 (1256382) 1256382..1256771 - 390 WP_000394511.1 hypothetical protein -
OO829_RS05915 (1256783) 1256783..1256911 - 129 WP_000344963.1 protein YdfB -
OO829_RS05920 (1256913) 1256913..1257068 - 156 WP_000379575.1 DUF1391 family protein -
OO829_RS05925 (1257346) 1257346..1257633 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO829_RS05930 (1257633) 1257633..1257824 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO829_RS05935 (1257852) 1257852..1258253 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO829_RS05940 (1258362) 1258362..1258634 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO829_RS05945 (1258618) 1258618..1259043 + 426 WP_000693855.1 toxin YdaT family protein -
OO829_RS05950 (1259250) 1259250..1259705 - 456 WP_000273724.1 hypothetical protein -
OO829_RS05955 (1259784) 1259784..1260875 + 1092 WP_001205823.1 hypothetical protein -
OO829_RS05960 (1260882) 1260882..1261628 + 747 WP_000788745.1 ATP-binding protein -
OO829_RS05965 (1261650) 1261650..1262420 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42355 WP_001303876.1 NZ_AP026114:c1257633-1257346 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42355 NZ_AP026114:c1257633-1257346 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42355 WP_000536233.1 NZ_AP026114:c1257824-1257633 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42355 NZ_AP026114:c1257824-1257633 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References