Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1890463..1891101 Replicon chromosome
Accession NZ_AP026110
Organism Escherichia coli strain CEC08123

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag OO855_RS09350 Protein ID WP_000813794.1
Coordinates 1890925..1891101 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OO855_RS09345 Protein ID WP_001270286.1
Coordinates 1890463..1890879 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO855_RS09325 (1885615) 1885615..1886556 - 942 WP_001251315.1 ABC transporter permease -
OO855_RS09330 (1886557) 1886557..1887570 - 1014 WP_000220402.1 ABC transporter ATP-binding protein -
OO855_RS09335 (1887588) 1887588..1888733 - 1146 WP_000047432.1 ABC transporter substrate-binding protein -
OO855_RS09340 (1888978) 1888978..1890384 - 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
OO855_RS09345 (1890463) 1890463..1890879 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OO855_RS09350 (1890925) 1890925..1891101 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OO855_RS09355 (1891323) 1891323..1891553 + 231 WP_000494244.1 YncJ family protein -
OO855_RS09360 (1891645) 1891645..1893606 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OO855_RS09365 (1893679) 1893679..1894215 - 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
OO855_RS09370 (1894307) 1894307..1895480 + 1174 Protein_1837 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T42292 WP_000813794.1 NZ_AP026110:c1891101-1890925 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T42292 NZ_AP026110:c1891101-1890925 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT42292 WP_001270286.1 NZ_AP026110:c1890879-1890463 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT42292 NZ_AP026110:c1890879-1890463 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References