Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1669376..1669847 | Replicon | chromosome |
| Accession | NZ_AP026110 | ||
| Organism | Escherichia coli strain CEC08123 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO855_RS08155 | Protein ID | WP_001303511.1 |
| Coordinates | 1669376..1669654 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO855_RS08160 | Protein ID | WP_001302048.1 |
| Coordinates | 1669656..1669847 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO855_RS08125 (1664602) | 1664602..1664853 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| OO855_RS08130 (1664926) | 1664926..1667397 | - | 2472 | WP_000048458.1 | exonuclease | - |
| OO855_RS08135 (1667490) | 1667490..1667681 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO855_RS08140 (1667678) | 1667678..1667866 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO855_RS08145 (1668435) | 1668435..1668653 | - | 219 | WP_001171930.1 | protein YdfC | - |
| OO855_RS08150 (1668725) | 1668725..1669024 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| OO855_RS08155 (1669376) | 1669376..1669654 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO855_RS08160 (1669656) | 1669656..1669847 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO855_RS08165 (1669868) | 1669868..1670239 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| OO855_RS08170 (1670337) | 1670337..1670639 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO855_RS08175 (1670636) | 1670636..1671061 | + | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO855_RS08180 (1671084) | 1671084..1672046 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO855_RS08185 (1672053) | 1672053..1672793 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO855_RS08190 (1672819) | 1672819..1673588 | + | 770 | Protein_1607 | DUF1627 domain-containing protein | - |
| OO855_RS08195 (1673604) | 1673604..1673999 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO855_RS08200 (1674056) | 1674056..1674640 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 1662216..1759250 | 97034 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42289 WP_001303511.1 NZ_AP026110:c1669654-1669376 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42289 NZ_AP026110:c1669654-1669376 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42289 WP_001302048.1 NZ_AP026110:c1669847-1669656 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42289 NZ_AP026110:c1669847-1669656 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|