Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1171202..1171680 Replicon chromosome
Accession NZ_AP026110
Organism Escherichia coli strain CEC08123

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag OO855_RS05415 Protein ID WP_001303876.1
Coordinates 1171202..1171489 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag OO855_RS05420 Protein ID WP_000536233.1
Coordinates 1171489..1171680 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO855_RS05380 (1166351) 1166351..1168822 - 2472 WP_000034474.1 exonuclease -
OO855_RS05385 (1168916) 1168916..1169107 - 192 WP_001098307.1 DUF1482 family protein -
OO855_RS05390 (1169104) 1169104..1169292 - 189 WP_000413705.1 cell division inhibition protein DicB -
OO855_RS05395 (1169866) 1169866..1170051 + 186 WP_001133046.1 hypothetical protein -
OO855_RS05400 (1170238) 1170238..1170627 - 390 WP_000394511.1 hypothetical protein -
OO855_RS05405 (1170639) 1170639..1170767 - 129 WP_000344963.1 protein YdfB -
OO855_RS05410 (1170769) 1170769..1170924 - 156 WP_000379575.1 DUF1391 family protein -
OO855_RS05415 (1171202) 1171202..1171489 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO855_RS05420 (1171489) 1171489..1171680 - 192 WP_000536233.1 hypothetical protein Antitoxin
OO855_RS05425 (1171708) 1171708..1172109 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
OO855_RS05430 (1172218) 1172218..1172490 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
OO855_RS05435 (1172474) 1172474..1172899 + 426 WP_000693855.1 toxin YdaT family protein -
OO855_RS05440 (1173106) 1173106..1173561 - 456 WP_000273724.1 hypothetical protein -
OO855_RS05445 (1173640) 1173640..1174731 + 1092 WP_001205823.1 hypothetical protein -
OO855_RS05450 (1174738) 1174738..1175484 + 747 WP_000788745.1 ATP-binding protein -
OO855_RS05455 (1175506) 1175506..1176276 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T42278 WP_001303876.1 NZ_AP026110:c1171489-1171202 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T42278 NZ_AP026110:c1171489-1171202 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT42278 WP_000536233.1 NZ_AP026110:c1171680-1171489 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT42278 NZ_AP026110:c1171680-1171489 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References