Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1004835..1005540 Replicon chromosome
Accession NZ_AP026110
Organism Escherichia coli strain CEC08123

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag OO855_RS04660 Protein ID WP_000539519.1
Coordinates 1005154..1005540 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag OO855_RS04655 Protein ID WP_001280945.1
Coordinates 1004835..1005164 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO855_RS04640 (999992) 999992..1000903 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
OO855_RS04645 (1001081) 1001081..1003429 + 2349 WP_000950320.1 EAL domain-containing protein -
OO855_RS04650 (1003437) 1003437..1004765 + 1329 WP_000086905.1 GGDEF domain-containing protein -
OO855_RS04655 (1004835) 1004835..1005164 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
OO855_RS04660 (1005154) 1005154..1005540 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OO855_RS04665 (1005766) 1005766..1007091 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
OO855_RS04670 (1007304) 1007304..1007687 + 384 WP_000497137.1 biofilm formation regulator BssR -
OO855_RS04675 (1007798) 1007798..1008913 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
OO855_RS04680 (1008910) 1008910..1009536 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T42277 WP_000539519.1 NZ_AP026110:c1005540-1005154 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T42277 NZ_AP026110:c1005540-1005154 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT42277 WP_001280945.1 NZ_AP026110:c1005164-1004835 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT42277 NZ_AP026110:c1005164-1004835 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References