Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2214331..2214802 | Replicon | chromosome |
| Accession | NZ_AP026108 | ||
| Organism | Escherichia coli strain CEC13091 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | OO842_RS11100 | Protein ID | WP_001303511.1 |
| Coordinates | 2214524..2214802 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | OO842_RS11095 | Protein ID | WP_001302048.1 |
| Coordinates | 2214331..2214522 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OO842_RS11055 (2209538) | 2209538..2210122 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| OO842_RS11060 (2210179) | 2210179..2210574 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| OO842_RS11065 (2210590) | 2210590..2211359 | - | 770 | Protein_2173 | DUF1627 domain-containing protein | - |
| OO842_RS11070 (2211385) | 2211385..2212125 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| OO842_RS11075 (2212132) | 2212132..2213094 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| OO842_RS11080 (2213117) | 2213117..2213542 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| OO842_RS11085 (2213539) | 2213539..2213841 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| OO842_RS11090 (2213939) | 2213939..2214310 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| OO842_RS11095 (2214331) | 2214331..2214522 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| OO842_RS11100 (2214524) | 2214524..2214802 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OO842_RS11105 (2215154) | 2215154..2215453 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| OO842_RS11110 (2215525) | 2215525..2215743 | + | 219 | WP_001171930.1 | protein YdfC | - |
| OO842_RS11115 (2216312) | 2216312..2216500 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| OO842_RS11120 (2216497) | 2216497..2216688 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| OO842_RS11125 (2216781) | 2216781..2219252 | + | 2472 | WP_000048458.1 | exonuclease | - |
| OO842_RS11130 (2219325) | 2219325..2219576 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleG7' | 2124929..2223088 | 98159 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T42248 WP_001303511.1 NZ_AP026108:2214524-2214802 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T42248 NZ_AP026108:2214524-2214802 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT42248 WP_001302048.1 NZ_AP026108:2214331-2214522 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT42248 NZ_AP026108:2214331-2214522 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|